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Strain: SD-F8em1Sage-/-/Novo

Symbol: SD-F8em1Sage-/-/Novo
Strain: SD-F8em1Sage-/SD-F8em1Sage-
Substrain: Novo
RGD ID: 11531091
Citation ID: RRID:RGD_11531091
Ontology ID: RS:0004212
Alleles: F8em1Sage
Also Known As: F8-/-; SD/Novo-F8em1Sage-/-; SD/Novo-F8em1Sage-/-; SD-F8^[em1Sage-/-]/Novo
Type: mutant
Available Source: Not Available
Origination: Novo Nordisk, Maaloev, Denmark
Description: The homozygous F8 mutant rats were produced by intercrossing the heterozygous ZFN mutants (SD-F8em1Sage+/-/Novo) to produce homozygous and heterozygous offspring. Genotype of the homozygous offspring was confirmed by PCR amplification of the deletion fragment which caused a premature translation stop.
Genetic Status: Homozygous
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.218140,848 - 172,330RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.018367,862 - 399,242RGD_MAPPER_PIPELINERnor6.0
Rnor_5.018413,447 - 444,491RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.418121,134 - 162,008RGD_MAPPER_PIPELINERGSC3.4





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Phenotype Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. A novel F8 -/- rat as a translational model of human hemophilia A. Nielsen LN, etal., J Thromb Haemost. 2014 Aug;12(8):1274-82. doi: 10.1111/jth.12635.
2. The severe spontaneous bleeding phenotype in a novel hemophilia A rat model is rescued by platelet FVIII expression. Shi Q, etal., Blood Adv. 2020 Jan 14;4(1):55-65. doi: 10.1182/bloodadvances.2019000944.
3. The F8(-/-) rat as a model of hemophilic arthropathy. Sørensen KR, etal., J Thromb Haemost. 2016 Jun;14(6):1216-25. doi: 10.1111/jth.13328. Epub 2016 May 10.

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-06-01 SD-F8em1Sage-/-/Novo    SD/Novo-F8em1Sage-/-    Symbol and/or name change 68913 APPROVED
2016-08-26 SD/Novo-F8em1Sage-/-    SD/Novo-F8em1Sage-/-    Name updated 68913 APPROVED
2016-08-26 SD/Novo-F8em1Sage-/-    SD/Novo-F8em1Sage-/-    Name updated 68913 APPROVED
2016-08-26 SD/Novo-F8em1Sage-/-    SD/Novo-F8em1Sage-/-    Name updated 68913 APPROVED
2016-08-26 SD/Novo-F8em1Sage-/-    SD/Novo-F8em1Sage-/-    Name updated 68913 APPROVED
2016-08-26 SD/Novo-F8em1Sage-/-    SD/Novo-F8em1Sage-/-    Name updated 68913 APPROVED
2016-08-26 SD/Novo-F8em1Sage-/-    SD/Novo-F8em1Sage-/-    Name updated 68913 APPROVED
2016-08-26 SD/Novo-F8em1Sage-/-    SD/Novo-F8em1Sage-/-    Name updated 68913 APPROVED
2016-08-26 SD/Novo-F8em1Sage-/-    SD/Novo-F8em1Sage-/-    Name updated 68913 APPROVED
2016-08-26 SD/Novo-F8em1Sage-/-    SD/Novo-F8em1Sage-/-    Name updated 68913 APPROVED