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Strain Registration

Strain: LE-Tg(Pvalb-tTA)15Hio

Symbol: LE-Tg(Pvalb-tTA)15Hio
Strain: LE-Tg(Pvalb-tTA)15
Substrain: Hio
RGD ID: 11041106
Citation ID: RRID:RGD_11041106
Ontology ID: RS:0004167
Also Known As: LE-Tg(mPvalb-tTA)Hio; NBRP Rat No: 0798
Type: transgenic
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: background strain #65306; Long-Evans rat #65288; Iar:Long-Evans #65289; Transgene #65306; (1) Parvalbumin (PV) promoter #65306; mouse derived (MGI:97821). PV is calcium-binding protein. (2) tetracycline transactivator (tTA) #65306; Fusion protein of tetracycline repressor (Escherichia coli-derived) and VP16 (Herpes simplex virus-derived). In the absence of Doxycycline (Dox), tTA binds to tetracycline-responsive element (TRE) and expression of TRE-controlled genes can be induced. Vector #65306; pBlueScript (Stratagene), pBACe3.6 (CHORI)
Last Known Status: Cryopreserved Sperm






References

References - curated
# Reference Title Reference Citation
1. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics tetracycline transactivator(tTA) is expressed in Parvalbumin-positive cells (neurons). In the absence of Dox, tTA binds to TRE and expression of TRE-controlled genes can be induced only in the Parvalbumin-positive cells. Expression of TRE-controlled genes can be repressed by Dox. (Tet-Off system) 1302502
strain_reproduction Maintained by mating between heterozygous rats. 1302502