Strain Report - Rat Genome Database

Name: F344- Bscl2 m1Kyo
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: F344-Bscl2^m1Kyo

Symbol:

F344-Bscl2^m1Kyo

Strain:

F344-Bscl2^m1

Substrain:

Kyo

RGD ID:

11040962

Citation ID:

RRID:RGD_11040962

Ontology ID:

RS:0004148

Alleles:

Bscl2^m1Kyo; Bscl2

Also Known As:

F344-Bscl2m1Kyo; SKOrat; NBRP Rat No: 0763; Bscl2sko/sko; F344-Bscl2^[m1Kyo]

Type:

mutant

Available Source:

National BioResource Project for the Rat in Japan

Origination:

National BioResource Project for the Rat in Japan

Description:

T239A mutation was found by screening of 4608DNA sample from ENU mutagenesis library KURMA. This strain has a T239A (L80X) nonsense mutation in Bscl2 gene.

Genetic Status:

Homozygous

Inbred Generations:

N10

Last Known Status:

Cryopreserved Sperm (as of 2019-01-09)

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	205,731,828 - 205,743,430	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	1	225,035,956 - 225,046,137	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	1	231,972,073 - 231,983,764	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	1	211,509,675 - 211,518,963	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

azoospermia (IMP)

Insulin Resistance (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal spatial working memory (IMP)

decreased body weight (IMP)

decreased brain weight (IMP)

decreased circulating leptin level (IMP)

decreased testis weight (IMP)

decreased white adipose tissue amount (IMP)

increased circulating cholesterol level (IMP)

increased circulating insulin level (IMP)

increased circulating triglyceride level (IMP)

increased lean body mass (IMP)

increased liver triglyceride level (IMP)

increased liver weight (IMP)

increased oxygen consumption (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis.	Ebihara C, etal., Hum Mol Genet. 2015 Aug 1;24(15):4238-49. doi: 10.1093/hmg/ddv156. Epub 2015 May 1.
2.	Strains registered by the National Bio Resource Project for the Rat in Japan	Personal Communication with NBRP
3.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines

Region

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_characteristics	Bscl2T239A homozygous mutated rat shows severe atrophy of adipose tissue, hypoleptinemia, abnormal glucose tolerance, increment of triglyceride levels in the liver. Bscl2T239A mutated male rats have small testes with sperm hypoplasia and are infertile.	1302502
strain_reproduction	crossing between heterozygous rats	1302502

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: F344-Bscl2m1Kyo

Mammalian Phenotype

Strain: F344-Bscl2^m1Kyo