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Strain: F344-Prkdcem2KyoIl2rgem6Kyo

Symbol: F344-Prkdcem2KyoIl2rgem6Kyo
Strain: F344-Prkdcem2Il2rgem6
Substrain: Kyo
RGD ID: 11040948
Citation ID: RRID:RGD_11040948
Ontology ID: RS:0004136
Alleles: Il2rg;   Il2rgem6Kyo;   Prkdcem2Kyo;   Prkdc
Also Known As: DSCID; NBRP Rat No: 0647; F344-Prkdcem2KyoIl2rgem6Kyo; F344-Prkdc^[em2Kyo]Il2rg^[em6Kyo]
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: This strain was established by Zinc-finger nucleases (ZFNs) method taregting rat Prkdc gene (227-bp deletion) and Il2rg gene (332-bp deletion). Background strain: F344/Stm
Coat Color: Albino
Inbred Generations: F3
Last Known Status: Cryopreserved Sperm (as of 2017-06-08)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21185,040,790 - 85,258,357RGD_MAPPER_PIPELINEmRatBN7.2
mRatBN7.2X66,395,330 - 66,399,026RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01189,293,547 - 89,510,948RGD_MAPPER_PIPELINERnor6.0
Rnor_6.0X71,165,378 - 71,169,078RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0X72,017,856 - 72,021,516RGD_MAPPER_PIPELINERnor5.0
Rnor_5.01192,347,175 - 92,565,022RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41186,951,420 - 87,169,229RGD_MAPPER_PIPELINERGSC3.4
RGSC_v3.4X89,342,055 - 89,345,715RGD_MAPPER_PIPELINERGSC3.4






References

References - curated
# Reference Title Reference Citation
1. Generation and characterization of severe combined immunodeficiency rats. Mashimo T, etal., Cell Rep. 2012 Sep 27;2(3):685-94. doi: 10.1016/j.celrep.2012.08.009. Epub 2012 Sep 13.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics This strain shows severe combined immunodeficiency_SCID_and growth retardation caused by a 227-bp deletion in the exon 1 of Prkdc gene and a 332-bp deletion in Il2rg gene. 1302502
strain_reproduction maintained by mating between Il2rg-homozygous/Prkdc-heterozygous rats 1302502