Strain Report - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Strain: WKY-Slc39a12em77Tja-/-

Symbol: WKY-Slc39a12em77Tja-/-
Strain: WKY-Slc39a12em77-/WKY-Slc39a12em77-
Substrain: Tja
Full Name: WKY-Slc39a12em77Tja-/WKY-Slc39a12em77Tja-
RGD ID: 10401848
Citation ID: RRID:RGD_10401848
Ontology ID: RS:0004055
Alleles: Slc39a12em77Tja
Previously known as: WKY-Slc39a12em77Tja-/-; WKY-Slc39a12em77-/WKY-Slc39a12em77-
Type: mutant
Source: MRC Clinical Centre, London, UK
Origin: ZFN mutant founders were backcrossed with WKY/Cruk to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. The resulting mutation 77 has a stop codon, 15 amino acids from the ZFN-binding site, that resulted in a 490 amino acids (54 kDa) truncated protein, 198 amino acids smaller than the WT protein.
Genetic Status: Homozygous
Last Known Status: Unknown
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21777,353,761 - 77,440,381RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01781,455,731 - 81,541,742RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01783,202,775 - 83,288,616RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41788,525,527 - 88,605,947RGD_MAPPER_PIPELINERGSC3.4

Disease Annotations     Click to see Annotation Detail View


References - curated
# Reference Title Reference Citation
1. RGD Strain RSO annotation pipeline RGD Automated Pipelines
2. The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia. Zhao L, etal., Nature. 2015 Aug 20;524(7565):356-60. doi: 10.1038/nature14620. Epub 2015 Aug 10.


Additional Information

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-16 WKY-Slc39a12em77Tja-/-  WKY-Slc39a12em77Tja-/WKY-Slc39a12em77Tja-  WKY-Slc39a12em77Tja-/-  WKY-Slc39a12em77Tja-/WKY-Slc39a12em77Tja-  Symbol and/or name change 68913 APPROVED