Strain Report - Rat Genome Database

Name: T2DN- Sirt3 em35Mcwi
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: T2DN-Sirt3^em35Mcwi

Symbol:

T2DN-Sirt3^em35Mcwi

Strain:

T2DN-Sirt3^em35

Substrain:

Mcwi

RGD ID:

10054456

Citation ID:

RRID:RGD_10054456

Ontology ID:

RS:0004015

Alleles:

Sirt3^em35Mcwi

Previously known as:

Strain00289; T2DN-Sirt3em35Mcwi

Type:

mutant

Source:

MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu

Origin:

CRISPR/Cas9 system was used to introduce a mutation in the Sirt3 gene of T2DN/Mcwi rat embryos. The resulting mutation is a 82-bp deletion of exon 3 in the Sirt3 gene.

Last Known Status:

Cryopreserved Sperm (as of 2018-10-22)

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	195,955,280 - 195,955,361	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	1	213,613,502 - 213,636,061	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	1	220,539,132 - 220,561,380	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	1	201,021,391 - 201,043,756	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

References

References - curated

#	Reference Title	Reference Citation
1.	Data registered by Dr. Melinda Dwinell’s group	Personal communication between Dr. Melinda Dwinell’s group and the RGD curators

Region

Allelic Variants

Name	Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Assembly
Sirt3em35Mcwi-var1	chr1	195955280	195955361	GTGTGTAGAGCCGCAGAAGCAGCTCCTTGTCGTGAAGCAGCCGAAGGAAGTAGTGAGCGACATTGGGCCTGTAGTGCCCAGG	-	deletion	mRatBN7.2

Additional Information

Nomenclature History

Date	Current Symbol	Previous Symbol	Description	Reference	Status
2016-10-05	T2DN-Sirt3^em35Mcwi	T2DN-Sirt3^em25Mcwi	Symbol updated	68687	APPROVED
2016-10-05	T2DN-Sirt3^em35Mcwi	T2DN-Sirt3^em25Mcwi	Symbol updated	68687	APPROVED
2016-03-16	T2DN-Sirt3^em25Mcwi	T2DN-Sirt3^em25Mcwi	Symbol updated	68687	APPROVED
2016-03-16	T2DN-Sirt3^em25Mcwi	T2DN-Sirt3^em25Mcwi	Symbol updated	68687	APPROVED
2016-03-16	T2DN-Sirt3^em25Mcwi	T2DN-Sirt3^em25Mcwi	Name updated	68913	APPROVED
2016-03-16	T2DN-Sirt3^em25Mcwi	T2DN-Sirt3^em25Mcwi	Name updated	68913	APPROVED
2015-08-26	T2DN-Sirt3^em25Mcwi	T2DN-Sirt35^em25Mcwi	Name updated	68913	APPROVED
2015-08-26	T2DN-Sirt3^em25Mcwi	T2DN-Sirt35^em25Mcwi	Name updated	68913	APPROVED
2015-08-26	T2DN-Sirt3^em25Mcwi	T2DN-Sirt35^em25Mcwi	Symbol updated	68687	APPROVED
2015-08-26	T2DN-Sirt3^em25Mcwi	T2DN-Sirt35^em25Mcwi	Symbol updated	68687	APPROVED
2015-08-06	T2DN-Sirt35^em25Mcwi	SS-Sirt35^em25Mcwi	Symbol updated	68687	APPROVED
2015-08-06	T2DN-Sirt35^em25Mcwi	SS-Sirt35^em25Mcwi	Name updated	68913	APPROVED
2015-08-06	T2DN-Sirt35^em25Mcwi	SS-Sirt35^em25Mcwi	Symbol updated	68687	APPROVED
2015-08-06	T2DN-Sirt35^em25Mcwi	SS-Sirt35^em25Mcwi	Name updated	68913	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: T2DN-Sirt3em35Mcwi

Strain: T2DN-Sirt3^em35Mcwi