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Strain Registration

Strain: LE/OrlBarth

Symbol: LE/OrlBarth
Strain: LE
Substrain: OrlBarth
Full Name: Long-Evans/Cryptorchid
RGD ID: 10047391
Citation ID: RRID:RGD_10047391
Ontology ID: RS:0003944
Also Known As: LE/Orl
Type: inbred
Available Source: Not Available
Origination: A.I. duPont Hospital for Children Life Science Center, Wilmington, Delaware
Description: Obtained from Centre Nationale de la Researche Scientifique, Orleans, France; then bred at A.I. duPont Hospital for Children Life Science Center, Wilmington, Delaware
Last Known Status: Unknown





Disease Annotations     Click to see Annotation Detail View
cryptorchidism  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Failure of shortening and inversion of the perinatal gubernaculum in the cryptorchid long-evans orl rat. Barthold JS, etal., J Urol. 2006 Oct;176(4 Pt 1):1612-7.
2. Polygenic inheritance of cryptorchidism susceptibility in the LE/orl rat. Barthold JS, etal., Mol Hum Reprod. 2016 Jan;22(1):18-34. doi: 10.1093/molehr/gav060. Epub 2015 Oct 26.
3. Data registered by Dr. Julia Barthold's group Personal communication between Dr. Julia Barthold's group and the RGD curators

Region

Strain Samples in RGD with Damaging Variants (Polyphen)
AssemblySample 
Rnor_5.0 LE/OrlBarth (UDEL) View Damaging Variants


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_anatomy at birth males showed anatomical difference of the fetal gubernacular bulb and a delay in migration to an ectopic position 2301308
strain_anatomy this gonadal maldescent can be surgically reversed by attaching the immature gubernaculum to the scortum approximately on day 21 2301308
strain_characteristics exhibit failure of the testis to descend into the scrotum 2301308