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Strain Registration

Strain: WTC/Kyo

Symbol: WTC/Kyo
Strain: WTC
Substrain: Kyo
RGD ID: 10047
Citation ID: RRID:RGD_10047
Ontology ID: RS:0001090
Previously known as: NBRP Rat No: 0020; MDC-01-76
Type: inbred
Source: National BioResource Project for the Rat in Japan
Origin: WTC was established as a coisogenic strain (tm<+/+>) from TRM (F18) in 1988. A missense mutation (c. 1061 C>T, p. A354V) in the hyperpolarization-activated cyclic nucleotide-gated 1 channel (Hcn1) gene (Ohno et al. 2015).
Coat Color: Albino
Inbred Generations: F60
Last Known Status: Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2018-01-03)





Phenotype Values via Phenominer Click to see Annotation Detail View

Related Phenotype Data for Term "WTC/Kyo" (RS:0001090)

Rat Strains:
Clinical Measurements:
Experimental Conditions:
Measurement Methods:
Disease Annotations     Click to see Annotation Detail View
Tremor  (IAGP)


Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
both testes wet weight to body weight ratio
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References

References - curated
# Reference Title Reference Citation
1. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
2. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
3. A set of highly informative rat simple sequence length polymorphism (SSLP) markers and genetically defined rat strains. Mashimo T, etal., BMC Genet. 2006 Apr 4;7:19.
4. Hcn1 is a tremorgenic genetic component in a rat model of essential tremor. Ohno Y, etal., PLoS One. 2015 May 13;10(5):e0123529. doi: 10.1371/journal.pone.0123529. eCollection 2015.
5. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines
7. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_other Control strain of TRM rat. 1302502
strain_reproduction Good breeding performance. 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-07 WTC/Kyo    WTC/Kyo    Name updated 68913 APPROVED
2012-05-07 WTC/Kyo    WTC/Kyo    Name updated 68913 APPROVED