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Strain Registration

Strain: CDS/Sasz

Symbol: CDS/Sasz
Strain: CDs
Substrain: Sasz
Full Name: Cohen diabetic-sensitive rat
RGD ID: 10045545
Citation ID: RRID:RGD_10045545
Ontology ID: RS:0003921
Also Known As: CDs/Sasz
Type: inbred
Available Source: Not Available
Origination: Hebrew University-Hadassah Medical School, Jerusalem, Israel
Description: Original breeders are from a colony at Hadassah University Hospital, Jerusalem, Israel: Professor Cohen AM et al. initiated the Cohen diabetic (CD) rat model at the Hadassah University Hospital in the 1950s to examine the role of constitutional (genetic) and environmental (dietary) factors in the development of type 2 diabetes mellitus. Since 1996, the original colony underwent a secondary inbreeding by Dr. Sarah Zangen designated by Prof. Cohen as responsible for the Cohen diabetic (CD) rat colony.
Inbred Generations: 60+
Last Known Status: Unknown





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Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Antidiabetic Effect of Interleukin-1beta Antibody Therapy Through beta-Cell Protection in the Cohen Diabetes-Sensitive Rat. Aharon-Hananel G, etal., Diabetes. 2015 May;64(5):1780-5. doi: 10.2337/db14-1018. Epub 2014 Dec 8.
2. Data registered by Dr. Sarah Zangen's group Personal communication between Dr. Sarah Zangen's group and the RGD curators
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. Dietary copper supplementation restores beta-cell function of Cohen diabetic rats: a link between mitochondrial function and glucose-stimulated insulin secretion. Weksler-Zangen S, etal., Am J Physiol Endocrinol Metab. 2013 May 15;304(10):E1023-34. doi: 10.1152/ajpendo.00036.2013. Epub 2013 Mar 19.
5. IL-1beta hampers glucose-stimulated insulin secretion in Cohen diabetic rat islets through mitochondrial cytochrome c oxidase inhibition by nitric oxide. Weksler-Zangen S, etal., Am J Physiol Endocrinol Metab. 2014 Mar;306(6):E648-57. doi: 10.1152/ajpendo.00451.2013. Epub 2014 Jan 14.
6. The newly inbred cohen diabetic rat: a nonobese normolipidemic genetic model of diet-induced type 2 diabetes expressing sex differences. Weksler-Zangen S, etal., Diabetes 2001 Nov;50(11):2521-9.
7. Impaired glucose-stimulated insulin secretion is coupled with exocrine pancreatic lesions in the Cohen diabetic rat. Weksler-Zangen S, etal., Diabetes. 2008 Feb;57(2):279-87. Epub 2007 Oct 31.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Using a more stringent criteria Dr. Zangen has set the threshold for the sensitive rats (CDs) at blood glucose levels >200 mg/dl following 1 month of a diabetogenic-diet (HSD) feeding. The CD rat model consists of two contrasting sub-strains: The CDs rat and the CD resistant (CDr) rat that sustains normoglycemia when fed either the HSD or a regular diet (RD) 10045544
strain_life_disease The sensitive Cohen diabetic rat (CDs) develops hyperglycemia (> 200 mg/dl ) when fed for 1 month on a diabetigenic high sucrose (72%) low copper(1.2 ppm) diet (HSD) but maintain normal blood glucose levels (<140 mg/dl) when fed on a regular diet (RD). 10045544
strain_reproduction Brother and sister mating 10045544

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-01-31 CDS/Sasz  Cohen diabetic-sensitive rat  CDs/Sasz  Cohen diabetic-sensitive rat  Symbol and/or name change 68913 APPROVED
2015-07-22 CDs/Sasz  Cohen diabetic-sensitive rat  CDS/Sza  Cohen diabetic-sensitive rat  Symbol updated 68687 APPROVED