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Strain Registration

Strain: MHS/Gib

Symbol: MHS/Gib
Strain: MHS
Substrain: Gib
Full Name: Milan Hypertensive Strain
RGD ID: 10025
Citation ID: RRID:RGD_10025
Ontology ID: RS:0000578
Previously known as: MDC-03-44
Type: inbred
Source: Department of Sciences and Biomedical Technologies, University of Milan, Milan, Italy
Origin: Outbred Wistar rats with brother x sister mating and selection for high systolic blood pressure
Last Known Status: Unknown





References

References - curated
# Reference Title Reference Citation
1. Genetic characterization of inbred strains of the rat (Rattus norvegicus). Bender K, etal., J Exp Anim Sci 1994 Aug;36(4-5):151-65.
2. Sequencing and chromosomal localization of Fabp6 and an intronless Fabp6 segment in the rat. Bonne A, etal., Mol Biol Rep 2003 Sep;30(3):173-6.
3. Na+/K+/Cl- cotransport in resealed ghosts from erythrocytes of the Milan hypertensive rats. Ferrari P, etal., Biochim Biophys Acta. 1992 Oct 19;1111(1):111-9. doi: 10.1016/0005-2736(92)90280-y.
4. Relationship between erythrocyte volume and sodium transport in the Milan hypertensive rat and age-dependent changes. Ferrari P, etal., J Hypertens. 1987 Apr;5(2):199-206. doi: 10.1097/00004872-198704000-00011.
5. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
6. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
7. Institute for Animal Experimentation University of Tokushima School of Medicine Institute for Animal Experimentation University of Tokushima School of Medicine
8. Use of simple sequence length polymorphisms for genetic characterization of rat inbred strains. Otsen M, etal., Mamm Genome 1995 Sep;6(9):595-601.
9. Sodium and glucose transport across renal brush border membranes of Milan hypertensive rats. Parenti P, etal., Hypertension. 1986 Oct;8(10):932-9. doi: 10.1161/01.hyp.8.10.932.
10. RGD Strain RSO annotation pipeline RGD Automated Pipelines
11. Genetic variation in coding regions between and within commonly used inbred rat strains. Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.
12. A new rat model for studying the calpain-calpastatin system. Soldati LP, etal., Lab Anim 1995 Oct;29(4):420-6.
13. Genetic mapping of blood pressure quantitative trait loci in Milan hypertensive rats. Zagato L, etal., Hypertension 2000 Nov;36(5):734-9.

Region

Strain QTL Data
Symbol Name Trait
Bp57 Blood pressure QTL 57 arterial blood pressure trait   (VT:2000000)    
Bp58 Blood pressure QTL 58 arterial blood pressure trait   (VT:2000000)    
Bp59 Blood pressure QTL 59 arterial blood pressure trait   (VT:2000000)    
Bp60 Blood pressure QTL 60 arterial blood pressure trait   (VT:2000000)    
Damaging Variants
Number of Damaging Variants
SamplemRatBN7.2Rnor_6.0Rnor_5.0RGSC_v3.4
MHS/Gib (ICL) 674
MHS/Gib (KNAW) 787
MHS/Gib (RGD) 1101


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Have elevated blood pressure after 2 months of age 1357950
strain_phys_biochem This strain was screened for genetic polymorphisms for 100 genomic loci in 55 genes ; Polymorphisms observed in this study can be found in NCBI dbSNP under accession numbers ss12588106 - ss12588203. 737878
strain_phys_biochem Lower inhibition of calpain by calpastain is observed in erythrocytes and kidney cells. 1357950