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Strain: M520/N

Symbol: M520/N
Strain: M520
Substrain: N
RGD ID: 10024
Citation ID: RRID:RRRC_00168
Ontology ID: RS:0000573
Type: inbred
Source: NIH Animal Genetic Resource, Rat Resource and Research Center
Origin: To N 1951 from Heston at F51. Developed by Curtis at Columbia University Institute for Cancer Research, 1920; to Heston, 1949 at F49.
Genetic Markers: a,c,h.
Coat Color: Albino.
Inbred Generations: F148.
Last Known Status: Cryopreserved Embryo





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Mammalian Phenotype

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References

References - curated
# Reference Title Reference Citation
1. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
2. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
3. Genetic Fine-Mapping and Identification of Candidate Genes and Variants for Adiposity Traits in Outbred Rats. Keele GR, etal., Obesity (Silver Spring). 2018 Jan;26(1):213-222. doi: 10.1002/oby.22075. Epub 2017 Nov 28.
4. NIH Rat Strain Data NIH Rat Strain Data
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines
6. Fine-mapping diabetes-related traits, including insulin resistance, in heterogeneous stock rats. Solberg Woods LC, etal., Physiol Genomics. 2012 Sep 4.

Region

Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
M520/N (KNAW) 536
M520/N (KNAW) 586
M520/N (MCW) 1291
M520/N (2020) 2545
M520/N (2020)


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_immunology Low antibody response to streptococcal group A carbohydrate, which is not MHC linked (Stankus and Leslie 1976). 1004
strain_immunology Low antibody response to streptococcal group A carbohydrate, which is not MHC linked (Stankus and Leslie 1976). 634612
strain_life_disease Intermediate survival to 2 years of age at 59% in males and 62% in females. There was a relatively high incidence of mild chronic renal disease and a high incidence of hydronephrosis which may make the strain unsuitable for long-term toxicity studies (though diet may have an important influence) (Solleveld and Boorman 1986). Susceptible to Cysticercus. NIH subline has a 21-25% incidence of adrenal medulla tumours. Susceptible to induction of tumours by 2-acetylaminofluorine (Symeonidis 1954). Low frequency of pancreatic exocrine tumours. By 12-15 months of age develop small local areas of nephritis that progress by 22-24 months to moderate to severe nephritis in 75% of animals (Snell 1967). About 33% of females over 18 months develop tumours of the uterus of endometrial origin. Adrenocortical adenomas (about 20% in males and 40% in females over 18 months of age), and phaeochromocytomas or preneoplastic nodules in adrenal medulla (about 67% of males over 21 months of age) (Snell 1965). Low blood pressure (21/23), reaching 121_1.2 (SEM) mmHg at 10 weeks of age. Resistant to development of methlycholanthrene -induced thyroiditis (Glover et al 1969). 1004
strain_life_disease Intermediate survival to 2 years of age at 59% in males and 62% in females. There was a relatively high incidence of mild chronic renal disease and a high incidence of hydronephrosis which may make the strain unsuitable for long-term toxicity studies (though diet may have an important influence) (Solleveld and Boorman 1986). Susceptible to Cysticercus. NIH subline has a 21-25% incidence of adrenal medulla tumours. Susceptible to induction of tumours by 2-acetylaminofluorine (Symeonidis 1954). Low frequency of pancreatic exocrine tumours. By 12-15 months of age develop small local areas of nephritis that progress by 22-24 months to moderate to severe nephritis in 75% of animals (Snell 1967). About 33% of females over 18 months develop tumours of the uterus of endometrial origin. Adrenocortical adenomas (about 20% in males and 40% in females over 18 months of age), and phaeochromocytomas or preneoplastic nodules in adrenal medulla (about 67% of males over 21 months of age) (Snell 1965). Low blood pressure (21/23), reaching 121_1.2 (SEM) mmHg at 10 weeks of age. Resistant to development of methlycholanthrene -induced thyroiditis (Glover et al 1969). 634612
strain_phys_biochem Low systolic blood pressure (16/17) (Hansen et al 1973). Low hepatic metabolism of anilene (9/10 in males, 7/10 in females), but high metabolism of ethylmorphine (1/10) (Page and Vesell 1969). Low 10-week body weight in males (5/23) (Tanase et al 1982). High relative heart weight in 10-week old males (21/23) (Tanase et al 1982). Lacks the phenobarbital-inducible cytochrome P450 2B2 (Cyp2B2) in hepatic microsomes due to a mutation in a single autosomal gene, with codominant inheritance with respect to protein and mRNA phenotypes (see also MW) (Omiecinski et al, 1992). 1004
strain_phys_biochem Low systolic blood pressure (16/17) (Hansen et al 1973). Low hepatic metabolism of anilene (9/10 in males, 7/10 in females), but high metabolism of ethylmorphine (1/10) (Page and Vesell 1969). Low 10-week body weight in males (5/23) (Tanase et al 1982). High relative heart weight in 10-week old males (21/23) (Tanase et al 1982). Lacks the phenobarbital-inducible cytochrome P450 2B2 (Cyp2B2) in hepatic microsomes due to a mutation in a single autosomal gene, with codominant inheritance with respect to protein and mRNA phenotypes (see also MW) (Omiecinski et al, 1992). 634612
strain_phys_biochem Low systolic blood pressure (16/17) (Hansen et al 1973). Low hepatic metabolism of anilene (9/10 in males, 7/10 in females), but high metabolism of ethylmorphine (1/10) (Page and Vesell 1969). Low 10-week body weight in males (5/23) (Tanase et al 1982). High relative heart weight in 10-week old males (21/23) (Tanase et al 1982). Lacks the phenobarbital-inducible cytochrome P450 2B2 (Cyp2B2) in hepatic microsomes due to a mutation in a single autosomal gene, with codominant inheritance with respect to protein and mRNA phenotypes (see also MW) (Omiecinski et al, 1992).  
strain_reproduction Good breeding performance (2/12) and intermediate litter size (6/12) (Hansen et al 1973). 1004
strain_reproduction Good breeding performance (2/12) and intermediate litter size (6/12) (Hansen et al 1973). 634612

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-04-18 M520/N    M520/N    Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00168 RGD