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Strain: GK/KyoSwe

Symbol: GK/KyoSwe
Strain: GK
Substrain: KyoSwe
Full Name: Goto Kakizaki
RGD ID: 10017
Citation ID: RRID:RGD_10017
Ontology ID: RS:0000118
Previously known as: MDC-01-66; GK/Swe
Type: inbred
Source: Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
Origin: Developed from outbred Wistar rats with selection for high glucose levels in and oral glucose tolerance test (Goto et al 1975).
Genetic Markers: c
Coat Color: Albino.
Inbred Generations: F40
Last Known Status: Unknown





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Mammalian Phenotype

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References

References - curated
# Reference Title Reference Citation
1. Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models. Dumas ME, etal., Nat Genet. 2007 Apr 15;.
2. A rat genetic linkage map including 67 new microsatellite markers. Fakhrai-Rad H, etal., Mamm Genome 1999 Nov;10(11):1102-5
3. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
4. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
5. Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat Galli J, etal., Nat Genet 1996 Jan;12(1):31-7
6. Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat Gauguier D, etal., Nat Genet 1996 Jan;12(1):38-43
7. High-resolution quantitative trait locus analysis reveals multiple diabetes susceptibility loci mapped to intervals<800 kb in the species-conserved Niddm1i of the GK rat. Granhall C, etal., Genetics. 2006 Nov;174(3):1565-72. Epub 2006 Sep 1.
8. Genetic loci for bone architecture determined by three-dimensional CT in crosses with the diabetic GK rat. Lagerholm S, etal., Bone. 2010 Dec;47(6):1039-47. Epub 2010 Aug 10.
9. Genetic regulation of bone traits is influenced by sex and reciprocal cross in F(2) progeny from GK and F344 rats. Lagerholm S, etal., J Bone Miner Res. 2009 Jun;24(6):1066-74.
10. Initial characterization of a rat model of diabetic nephropathy. Nobrega MA, etal., Diabetes 2004 Mar;53(3):735-42.
11. Distinct genetic regulation of progression of diabetes and renal disease in the Goto-Kakizaki rat. Nobrega MA, etal., Physiol Genomics. 2009 Sep 9;39(1):38-46. Epub 2009 Jul 7.
12. RGD Strain RSO annotation pipeline RGD Automated Pipelines
13. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
14. Sequence analysis of the complete mitochondrial DNA in 10 commonly used inbred rat strains. Schlick NE, etal., Am J Physiol Cell Physiol. 2006 Dec;291(6):C1183-92. Epub 2006 Jul 19.

Region

Strain QTL Data
Symbol Name Trait
Bmd69 Bone mineral density QTL 69 tibia mineral mass   (VT:1000283)    
Bmd70 Bone mineral density QTL 70 tibia mineral mass   (VT:1000283)    
Bmd71 Bone mineral density QTL 71 tibia mineral mass   (VT:1000283)    
Bmd72 Bone mineral density QTL 72 tibia mineral mass   (VT:1000283)    
Bmd73 Bone mineral density QTL 73 tibia mineral mass   (VT:1000283)    
Bmd74 Bone mineral density QTL 74 tibia mineral mass   (VT:1000283)    
Bmd75 Bone mineral density QTL 75 tibia mineral mass   (VT:1000283)    
Bmd76 Bone mineral density QTL 76 tibia mineral mass   (VT:1000283)    
Bmd77 Bone mineral density QTL 77 tibia mineral mass   (VT:1000283)    
Bmd78 Bone mineral density QTL 78 tibia mineral mass   (VT:1000283)    
Bmd79 Bone mineral density QTL 79 tibia mineral mass   (VT:1000283)    
Bmd80 Bone mineral density QTL 80 tibia mineral mass   (VT:1000283)    
Bmd81 Bone mineral density QTL 81 tibia mineral mass   (VT:1000283)    
Bmd82 Bone mineral density QTL 82 tibia mineral mass   (VT:1000283)    
Bmd83 Bone mineral density QTL 82 tibia mineral mass   (VT:1000283)    
Bmd84 Bone mineral density QTL 84 tibia mineral mass   (VT:1000283)    
Bmd85 Bone mineral density QTL 85 tibia mineral mass   (VT:1000283)    
Bmd86 Bone mineral density QTL 86 tibia mineral mass   (VT:1000283)    
Bmd87 Bone mineral density QTL 87 tibia mineral mass   (VT:1000283)    
Bss100 Bone structure and strength QTL 100 tibia area   (VT:1000281)    
Bss101 Bone structure and strength QTL 101 tibia strength trait   (VT:1000284)    
Bss102 Bone structure and strength QTL 102 tibia strength trait   (VT:1000284)    
Bss103 Bone structure and strength QTL 103 tibia strength trait   (VT:1000284)    
Bss104 Bone structure and strength QTL 104 tibia area   (VT:1000281)    
Bss51 Bone structure and strength QTL 51 tibia length   (VT:0004357)    
Bss52 Bone structure and strength QTL 52 body length   (VT:0001256)    
Bss53 Bone structure and strength QTL 53 tibia length   (VT:0004357)    
Bss54 Bone structure and strength QTL 54 tibia area   (VT:1000281)    
Bss55 Bone structure and strength QTL 55 tibia size trait   (VT:0100001)    
Bss56 Bone structure and strength QTL 56 tibia size trait   (VT:0100001)    
Bss57 Bone structure and strength QTL 57 tibia strength trait   (VT:1000284)    
Bss58 Bone structure and strength QTL 58 tibia strength trait   (VT:1000284)    
Bss59 Bone structure and strength QTL 59 long bone metaphysis morphology trait   (VT:0000133)    
Bss60 Bone structure and strength QTL 60 tibia length   (VT:0004357)    
Bss61 Bone structure and strength QTL 61 tibia area   (VT:1000281)    
Bss62 Bone structure and strength QTL 62 tibia size trait   (VT:0100001)    
Bss63 Bone structure and strength QTL 63 tibia strength trait   (VT:1000284)    
Bss64 Bone structure and strength QTL 64 tibia strength trait   (VT:1000284)    
Bss65 Bone structure and strength QTL 65 long bone metaphysis morphology trait   (VT:0000133)    
Bss66 Bone structure and strength QTL 66 tibia length   (VT:0004357)    
Bss67 Bone structure and strength QTL 67 tibia area   (VT:1000281)    
Bss68 Bone structure and strength QTL 68 tibia size trait   (VT:0100001)    
Bss69 Bone structure and strength QTL 69 tibia strength trait   (VT:1000284)    
Bss70 Bone structure and strength QTL 70 tibia strength trait   (VT:1000284)    
Bss71 Bone structure and strength QTL 71 long bone metaphysis morphology trait   (VT:0000133)    
Bss72 Bone structure and strength QTL 72 tibia area   (VT:1000281)    
Bss73 Bone structure and strength QTL 73 tibia size trait   (VT:0100001)    
Bss74 Bone structure and strength QTL 74 tibia strength trait   (VT:1000284)    
Bss75 Bone structure and strength QTL 75 body length   (VT:0001256)    
Bss76 Bone structure and strength QTL 76 tibia size trait   (VT:0100001)    
Bss77 Bone structure and strength QTL 77 tibia size trait   (VT:0100001)    
Bss78 Bone structure and strength QTL 78 tibia strength trait   (VT:1000284)    
Bss79 Bone structure and strength QTL 79 tibia size trait   (VT:0100001)    
Bss80 Bone structure and strength QTL 80 tibia strength trait   (VT:1000284)    
Bss81 Bone structure and strength QTL 81 body length   (VT:0001256)    
Bss82 Bone structure and strength QTL 82 tibia size trait   (VT:0100001)    
Bss83 Bone structure and strength QTL 83 tibia size trait   (VT:0100001)    
Bss84 Bone structure and strength QTL 84 tibia strength trait   (VT:1000284)    
Bss85 Bone structure and strength QTL 85 long bone metaphysis morphology trait   (VT:0000133)    
Bss86 Bone structure and strength QTL 86 tibia area   (VT:1000281)    
Bss87 Bone structure and strength QTL 87 tibia area   (VT:1000281)    
Bss88 Bone structure and strength QTL 88 tibia size trait   (VT:0100001)    
Bss89 Bone structure and strength QTL 89 tibia size trait   (VT:0100001)    
Bss90 Bone structure and strength QTL 90 tibia area   (VT:1000281)    
Bss91 Bone structure and strength QTL 91 tibia area   (VT:1000281)    
Bss92 Bone structure and strength QTL 92 tibia area   (VT:1000281)    
Bss93 Bone structure and strength QTL 93 tibia size trait   (VT:0100001)    
Bss94 Bone structure and strength QTL 94 tibia area   (VT:1000281)    
Bss95 Bone structure and strength QTL 95 tibia area   (VT:1000281)    
Bss96 Bone structure and strength QTL 96 tibia size trait   (VT:0100001)    
Bss97 Bone structure and strength QTL 97 tibia size trait   (VT:0100001)    
Bss98 Bone structure and strength QTL 98 tibia strength trait   (VT:1000284)    
Bss99 Bone structure and strength QTL 99 tibia area   (VT:1000281)    
Bw17 Body weight QTL 17 body mass   (VT:0001259)    
Bw19 Body weight QTL 19 body mass   (VT:0001259)    
Bw23 Body weight QTL 23 body mass   (VT:0001259)    
Bw96 Body weight QTL 96 body mass   (VT:0001259)    
Gluco57 Glucose level QTL 57 blood glucose amount   (VT:0000188)    
Gluco58 Glucose level QTL 58 blood glucose amount   (VT:0000188)    
Gluco59 Glucose level QTL 59 blood glucose amount   (VT:0000188)    
Gluco60 Glucose level QTL 60 blood glucose amount   (VT:0000188)    
Niddm1 Non-insulin dependent diabetes mellitus QTL 1 blood glucose amount   (VT:0000188)    
Niddm10 Non-insulin dependent diabetes mellitus QTL 10 blood glucose amount   (VT:0000188)    
Niddm11 Non-insulin dependent diabetes mellitus QTL 11 blood insulin amount   (VT:0001560)    
Niddm12 Non-insulin dependent diabetes mellitus QTL 12 blood glucose amount   (VT:0000188)    
Niddm2 Non-insulin dependent diabetes mellitus QTL 2 blood glucose amount   (VT:0000188)    
Niddm3 Non-insulin dependent diabetes mellitus QTL 3 blood glucose amount   (VT:0000188)    
Niddm61 Non-insulin dependent diabetes mellitus QTL 61 blood insulin amount   (VT:0001560)    
Niddm62 Non-insulin dependent diabetes mellitus QTL 62 insulin secretion trait   (VT:0003564)    
Niddm7 Non-insulin dependent diabetes mellitus QTL 7 blood glucose amount   (VT:0000188)    
Niddm8 Non-insulin dependent diabetes mellitus QTL 8 blood insulin amount   (VT:0001560)    
Niddm9 Non-insulin dependent diabetes mellitus QTL 9 blood insulin amount   (VT:0001560)    
Pur21 Proteinuria QTL 21 urine protein amount   (VT:0005160)    
Pur22 Proteinuria QTL 22 urine protein amount   (VT:0005160)    
Rf57 Renal function QTL 57 kidney glomerulus morphology trait   (VT:0005325)    
Rf58 Renal function QTL 58 kidney glomerulus morphology trait   (VT:0005325)    
Scl66 Serum cholesterol level QTL 66 blood cholesterol amount   (VT:0000180)    
Stl24 Serum triglyceride level QTL 24 blood triglyceride amount   (VT:0002644)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Shows several non-insulin dependent diabetes mellitus (NIDDM)-related phenotypes including fasting hyperglycemia, impared secretion of insulin in response to glucose both in vivo and inisolated pancreata, hepatic and peripheral insulin resistance, with late complications which include nephropathy and neuropathy (Suzuki et al, 1992, Hughes et al, 1994, Villar-Palasi and Farese,1994). Three independent loci affecting NIDDM, and a major locus affecting body weight but not glucose tolerance have been identified in a cross with non-diabetic F344 rats (Galli et al, 1996). 61082
strain_characteristics Shows several non-insulin dependent diabetes mellitus (NIDDM)-related phenotypes including fasting hyperglycemia, impared secretion of insulin in response to glucose both in vivo and inisolated pancreata, hepatic and peripheral insulin resistance, with late complications which include nephropathy and neuropathy (Suzuki et al, 1992, Hughes et al, 1994, Villar-Palasi and Farese,1994). Three independent loci affecting NIDDM, and a major locus affecting body weight but not glucose tolerance have been identified in a cross with non-diabetic F344 rats (Galli et al, 1996). 634612
strain_other These are a good model for genetic susceptibility to Non-insulin dependent diabetes mellitus in non-obese individuals. 61082