RGD Reference Report - The MHC-encoded TAP1/LMP2 bidirectional promoter is down-regulated in highly oncogenic adenovirus type 12 transformed cells. - Rat Genome Database

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The MHC-encoded TAP1/LMP2 bidirectional promoter is down-regulated in highly oncogenic adenovirus type 12 transformed cells.

Authors: Proffitt, JA  Blair, GE 
Citation: Proffitt JA and Blair GE, FEBS Lett. 1997 Jan 3;400(2):141-4.
RGD ID: 9850285
Pubmed: PMID:9001385   (View Abstract at PubMed)

Cells transformed by human adenovirus 12 (Ad12) exhibit extremely low surface levels of MHC class I molecules and contain reduced levels of class I heavy chain mRNAs. We report that levels of MHC-encoded TAP1 and LMP2 mRNAs are also down-regulated in Ad12-transformed rat cells, and that transcription of rat TAP1 and LMP2 transcripts is directed from a 564 bp intergenic region which is significantly less active in Ad12-transformed cells compared to those transformed with Ad5. Our results suggest that, in common with MHC class I gene expression, TAP1 and LMP2 gene expression is reduced mainly at the level of transcription in Ad12-transformed cells.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cellular response to virus  IEP 9850285 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Psmb9  (proteasome 20S subunit beta 9)


Additional Information