RGD Reference Report - Administration of anti-Reg I and anti-PAPII antibodies worsens pancreatitis. - Rat Genome Database

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Administration of anti-Reg I and anti-PAPII antibodies worsens pancreatitis.

Authors: Viterbo, D  Callender, GE  DiMaio, T  Mueller, CM  Smith-Norowitz, T  Zenilman, ME  Bluth, MH 
Citation: Viterbo D, etal., JOP. 2009 Jan 8;10(1):15-23.
RGD ID: 9850139
Pubmed: PMID:19129610   (View Abstract at PubMed)
PMCID: PMC2666878   (View Article at PubMed Central)

CONTEXT: The regeneration protein family (Reg), which includes Reg I and PAPII, is expressed in pancreas acinar cells, and increases in acute pancreatitis. We have demonstrated that Reg gene knockdown worsens severity of acute pancreatitis in the rat and hypothesize that the proteins offer a protective effect in this disease. OBJECTIVE: We investigated the ability of anti-Reg and anti-PAP antibody to neutralize pancreatic Reg protein and affect pancreatitis severity. INTERVENTION: Pancreatitis was induced in rats by retrograde ductal injection of 4% sodium taurocholate. ANIMALS: Eighty-four rats: 48 with induced pancreatitis, 30 sham operated, and 6 normal animals. SETTING: Intraductal anti-Reg I and/or anti-PAPII antibody was administered at induced pancreatitis and sham operated subgroups of 6 rats each. MAIN OUTCOME MEASURE: Serum and pancreata were harvested 24 and/or 48 hours later and assessed for pancreatitis severity by pancreatic wet weight, serum C-reactive protein (CRP), amylase, PAPII levels, and histopathology. RESULTS: Animals induced with pancreatitis with administration of anti-Reg/PAP antibodies had significantly higher wet weights compared with taurocholate and histopathological analysis revealed that anti-Reg/PAP treated animals had worse tissue inflammation and necrosis compared with controls. Serum CRP, amylase, and Reg levels did not significantly differ between experimental and sham control groups. CONCLUSIONS: Administration of anti-Reg/PAP antibody worsened taurocholate-induced organ specific pancreatitis. These data suggest that the Reg family of proteins is protective in acute pancreatitis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Acute Experimental Pancreatitis severityISOReg1a (Rattus norvegicus)9850139; 9850139 RGD 
Acute Experimental Pancreatitis severityIMP 9850139 RGD 
acute pancreatitis severityIMP 9850139 RGD 
acute pancreatitis severityISOReg3a (Rattus norvegicus)9850139 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Reg1a  (regenerating family member 1 alpha)
Reg3a  (regenerating islet-derived 3 alpha)

Genes (Mus musculus)
Reg1  (regenerating islet-derived 1)
Reg3a  (regenerating islet-derived 3 alpha)

Genes (Homo sapiens)
REG1A  (regenerating family member 1 alpha)

Objects referenced in this article
Gene Reg3b regenerating family member 3 beta Rattus norvegicus

Additional Information