RGD Reference Report - Involvement of REG Ialpha protein in the regeneration of ductal epithelial cells in the minor salivary glands of patients with Sjogren's syndrome. - Rat Genome Database

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Involvement of REG Ialpha protein in the regeneration of ductal epithelial cells in the minor salivary glands of patients with Sjogren's syndrome.

Authors: Kimura, T  Fukui, H  Sekikawa, A  Yamagishi, H  Ichikawa, K  Tomita, S  Fujii, S  Imura, J  Kawamata, H  Chiba, T  Imai, Y  Fujimori, T 
Citation: Kimura T, etal., Clin Exp Immunol. 2009 Jan;155(1):16-20. doi: 10.1111/j.1365-2249.2008.03806.x. Epub 2008 Nov 6.
RGD ID: 9850137
Pubmed: PMID:19016805   (View Abstract at PubMed)
PMCID: PMC2665674   (View Article at PubMed Central)
DOI: DOI:10.1111/j.1365-2249.2008.03806.x   (Journal Full-text)

The regenerating gene (Reg) was originally isolated from regenerating rat pancreatic islets and revealed recently to constitute a multi-gene family in humans. REG Ialpha protein is known to be overexpressed not only in various human inflammatory diseases but also in various experimental models of inflammation in animal tissues. However, its involvement in pathophysiology of the minor salivary gland (MSG) is not clear. We investigated REG Ialpha expression in the MSG of patients with primary Sjogren's syndrome (SS) and assessed its role in ductal epithelial cell proliferation in such tissues. Lip biopsy specimens were obtained from 40 patients with primary SS and examined using immunohistochemistry for REG Ialpha protein, Ki67 and single-strand DNA (ssDNA). The relationships among clinicopathological factors and expression of REG Ialpha protein, Ki67 and ssDNA in the MSG were then analysed. REG Ialpha protein was expressed rarely in ductal epithelial cells of the normal MSG but was apparently overexpressed in those of patients with SS. The labelling indices for both Ki67 and ssDNA in the ductal cells of the MSGs were significantly higher in SS patients than in controls. Moreover, these labelling indices were significantly higher in REG Ialpha-positive than in negative SS patients. REG Ialpha protein may play a role in the regeneration of ductal epithelial cells in the MSGs of patients with SS.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Sjogren's syndrome  IEP 9850137protein:increased expression:minor salivary gland and salivary ductal epithelium (human)RGD 
Sjogren's syndrome  ISOREG1A (Homo sapiens)9850137; 9850137protein:increased expression:minor salivary gland and salivary ductal epithelium (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Reg1a  (regenerating family member 1 alpha)

Genes (Mus musculus)
Reg1  (regenerating islet-derived 1)

Genes (Homo sapiens)
REG1A  (regenerating family member 1 alpha)


Additional Information