RGD Reference Report - Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein. - Rat Genome Database

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Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein.

Authors: Watanabe, T  Yonemura, Y  Yonekura, H  Suzuki, Y  Miyashita, H  Sugiyama, K  Moriizumi, S  Unno, M  Tanaka, O  Kondo, H 
Citation: Watanabe T, etal., Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3589-92.
RGD ID: 9850123
Pubmed: PMID:8170952   (View Abstract at PubMed)
PMCID: PMC43625   (View Article at PubMed Central)

We previously isolated from a rat regenerating islet cDNA library a gene named Reg, which is expressed in regenerating islets but is not expressed in normal islets. Here we examined the effect of rat Reg protein on pancreatic beta-cell replication using both 90% depancreatized rats and isolated islets. The depancreatized rats that received i.p. administration of recombinant rat Reg protein (1 mg/kg per day) for 2 months showed amelioration of the surgical diabetes, as evidenced by a significant decrease in blood glucose with an increased beta-cell mass in the residual pancreas. In isolated rat islets, Reg protein (18-180 nM: 0.3-3 micrograms/ml) significantly increased [3H]thymidine incorporation into the nuclei of beta cells. These results indicate that Reg protein is a growth factor for pancreatic beta cells and also suggest that the administration of Reg protein could be used as another therapeutic approach for diabetes mellitus.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Diabetes Mellitus treatmentISOReg1a (Rattus norvegicus)9850123; 9850123 RGD 
Experimental Diabetes Mellitus treatmentIDA 9850123 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Reg1a  (regenerating family member 1 alpha)

Genes (Mus musculus)
Reg1  (regenerating islet-derived 1)

Genes (Homo sapiens)
REG1A  (regenerating family member 1 alpha)


Additional Information