RGD Reference Report - Neurogranin is locally concentrated in rat cortical and hippocampal neurons. - Rat Genome Database

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Neurogranin is locally concentrated in rat cortical and hippocampal neurons.

Authors: Neuner-Jehle, M  Denizot, JP  Mallet, J 
Citation: Neuner-Jehle M, etal., Brain Res. 1996 Sep 9;733(1):149-54.
RGD ID: 9835422
Pubmed: PMID:8891262   (View Abstract at PubMed)

The rat protein kinase C substrate neurogranin has a granular distribution in cortical and hippocampal neurons. We demonstrate that in these cells, granular labelling corresponds to a local concentration of neurogranin-immunoreactivity at both the membranes of mitochondria and trans-Golgi vesicles and soma-proximal dendritic shaft and spinal head structures. Our findings suggest that the function of neurogranin could be affected by protein assembly at these cellular sites.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
dendritic spine head  IDA 9835422 RGD 
mitochondrial membrane  IDA 9835422 RGD 
trans-Golgi network transport vesicle membrane  IDA 9835422 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nrgn  (neurogranin)


Additional Information