RGD Reference Report - Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease. - Rat Genome Database

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Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease.

Authors: Guo, Q  Fu, W  Xie, J  Luo, H  Sells, SF  Geddes, JW  Bondada, V  Rangnekar, VM  Mattson, MP 
Citation: Guo Q, etal., Nat Med. 1998 Aug;4(8):957-62.
RGD ID: 9835364
Pubmed: PMID:9701251   (View Abstract at PubMed)

Prostate apoptosis response-4 (Par-4) is a protein containing both a leucine zipper and a death domain that was isolated by differential screening for genes upregulated in prostate cancer cells undergoing apoptosis. Par-4 is expressed in the nervous system, where its function is unknown. In Alzheimer disease (AD), neurons may die by apoptosis, and amyloid beta-protein (A beta) may play a role in this. We report here that Par-4 expression is increased in vulnerable neurons in AD brain and is induced in cultured neurons undergoing apoptosis. Blockade of Par-4 expression or function prevented neuronal apoptosis induced by Ab and trophic factor withdrawal. Par-4 expression was enhanced, and mitochondrial dysfunction and apoptosis exacerbated, in cells expressing presenilin-1 mutations associated with early-onset inherited AD.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alzheimer's disease  IEP 9835364mRNA and protein:increased expression:brain:RGD 
Alzheimer's disease  ISOPAWR (Homo sapiens)9835364; 9835364mRNA and protein:increased expression:brain:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pawr  (pro-apoptotic WT1 regulator)

Genes (Mus musculus)
Pawr  (PRKC, apoptosis, WT1, regulator)

Genes (Homo sapiens)
PAWR  (pro-apoptotic WT1 regulator)


Additional Information