RGD Reference Report - Voltage-dependent K+ channel beta subunits in muscle: differential regulation during postnatal development and myogenesis. - Rat Genome Database

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Voltage-dependent K+ channel beta subunits in muscle: differential regulation during postnatal development and myogenesis.

Authors: Grande, M  Suarez, E  Vicente, R  Canto, C  Coma, M  Tamkun, MM  Zorzano, A  Guma, A  Felipe, A 
Citation: Grande M, etal., J Cell Physiol. 2003 May;195(2):187-93.
RGD ID: 9743957
Pubmed: PMID:12652645   (View Abstract at PubMed)
DOI: DOI:10.1002/jcp.10203   (Journal Full-text)

Voltage-dependent potassium channels contribute to the electrical properties of nerve and muscle by affecting action potential shape and duration. The complexity of the currents generated is further enhanced by the presence of accessory beta subunits. Here we report that while all Kvbeta mRNA isoforms are present in rat brain, muscle tissues express only Kvbeta1 (Kvbeta1.1-Kvbeta1.3) and Kvbeta2, but not Kvbeta3. Kvbeta subunits were close regulated through post-natal development in brain and striated muscle, as well as during myogenesis in the rat skeletal muscle cell line L6E9. While the alternatively spliced Kvbeta mRNA products from Kvbeta1 gene were differentially expressed, Kvbeta2.1 was associated with myogenesis. These results show that Kvbeta genes are strongly regulated in muscle and suggest a physiological role for voltage-gated K(+) channels during development and myotube formation.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
diaphragm development  IEP 9743957 RGD 
heart development  IEP 9743957 RGD 
myoblast differentiation  IEP 9743957; 9743957 RGD 
skeletal muscle tissue development  IEP 9743957 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Kcnab1  (potassium voltage-gated channel subfamily A regulatory beta subunit 1)
Kcnab2  (potassium voltage-gated channel subfamily A regulatory beta subunit 2)


Additional Information