RGD Reference Report - Hippocalcin in the olfactory epithelium: a mediator of second messenger signaling. - Rat Genome Database

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Hippocalcin in the olfactory epithelium: a mediator of second messenger signaling.

Authors: Mammen, A  Simpson, PJ  Nighorn, A  Imanishi, Y  Palczewski, K  Ronnett, GV  Moon, C 
Citation: Mammen A, etal., Biochem Biophys Res Commun. 2004 Oct 1;322(4):1131-9.
RGD ID: 9686438
Pubmed: PMID:15336960   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2004.07.123   (Journal Full-text)

Intracellular Ca2+ plays an important role in a variety of second messenger cascades. The function of Ca2+ is mediated, in part, by Ca2+-binding proteins such as calmodulin, calretinin, calbindin, neurocalcin, recoverin, and visinin-like proteins (VILIPs). These proteins are highly expressed in rat olfactory receptor neurons (ORNs) and are localized to distinct intracellular regions. In the present study, we have identified another Ca2+-binding protein, hippocalcin, in the rat olfactory epithelium (OE). Olfactory/brain hippocalcin shows high sequence homology with hippocalcins expressed in mice and humans. Hippocalcin was predominantly localized to the olfactory cilia, the site of the initial events of olfactory signal transduction, and was found to regulate the activity of ciliary adenylate cyclases (ACs) and particulate guanylyl cyclases (GCs) in a Ca2+-dependent manner. These data indicate that hippocalcin is expressed in rat ORNs, and is likely to regulate second messenger cascades in a Ca2+-dependent manner.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HpcaRatnegative regulation of guanylate cyclase activity  IDA  RGD 
HpcaRatpositive regulation of adenylate cyclase activity  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hpca  (hippocalcin)


Additional Information