RGD Reference Report - Nuclear compartmentalization and dynamics of the poly(A)-binding protein nuclear 1 (PABPN1) inclusions in supraoptic neurons under physiological and osmotic stress conditions. - Rat Genome Database

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Nuclear compartmentalization and dynamics of the poly(A)-binding protein nuclear 1 (PABPN1) inclusions in supraoptic neurons under physiological and osmotic stress conditions.

Authors: Villagra, NT  Bengoechea, R  Vaque, JP  Llorca, J  Berciano, MT  Lafarga, M 
Citation: Villagra NT, etal., Mol Cell Neurosci. 2008 Mar;37(3):622-33. doi: 10.1016/j.mcn.2007.12.012. Epub 2007 Dec 15.
RGD ID: 9686377
Pubmed: PMID:18255312   (View Abstract at PubMed)
DOI: DOI:10.1016/j.mcn.2007.12.012   (Journal Full-text)

Nuclear aggregation of the expanded polyalanine tract in the poly(A)-binding protein nuclear 1 (PABPN1) is the pathological hallmark of oculopharyngeal muscular dystrophy. However, wild type PABPN1 aggregates into nuclear inclusion in oxytocin-producing neurons under physiological conditions. In this study we have analyzed the nuclear organization and dynamics of PABPN1 inclusions in oxytocin-producing neurons. We demonstrated that PABPN1 inclusions represent a distinct compartment of the interchromatin region. They establish a spatial relationship with nuclear speckles, Cajal bodies and clastosomes. PABPN1 inclusions accumulate poly(A) RNA, but do not concentrate highly expressed mRNAs in oxytocin producing neurons and the mRNA-binding proteins hnRNP C, Y14 and REF. PABPN1 inclusions are dynamic structures that appear during the postnatal period and their number decrease in response to the activation of transcription. Our results support that the RNA retained in the PABPN1 inclusions is a noncoding regulatory RNA involved in some aspects of nuclear RNA metabolism.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
nuclear inclusion body  IDA 9686377 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pabpn1  (poly(A) binding protein, nuclear 1)


Additional Information