RGD Reference Report - What is the functional significance of the unique location of glutaredoxin 1 (GRx1) in the intermembrane space of mitochondria? - Rat Genome Database
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What is the functional significance of the unique location of glutaredoxin 1 (GRx1) in the intermembrane space of mitochondria?

Authors: Pai, HV  Starke, DW  Lesnefsky, EJ  Hoppel, CL  Mieyal, JJ 
Citation: Pai HV, etal., Antioxid Redox Signal. 2007 Nov;9(11):2027-33.
RGD ID: 9686049
Pubmed: (View Article at PubMed) PMID:17845131
DOI: Full-text: DOI:10.1089/ars.2007.1642

Glutaredoxins (GRx) catalyze reversible protein glutathionylation. They are implicated in sulfhydryl homeostasis and regulation of redox signal transduction, controlling various cellular processes like DNA synthesis, defense against oxidative stress, apoptosis signaling, and DNA-binding of transcription factors. Two isoforms of GRx are well characterized in mammals: GRx1, the "cytosolic" form, and GRx2, the "mitochondrial" form. Here we report documentation of GRx1 in mitochondria, localized exclusively in the intermembrane space and segregated from GRx2, localized exclusively in the mitochondrial matrix. We hypothesize that GRx1 and GRx2 in their unique locations regulate different functions of the mitochondria via reversible S-glutathionylation.

Annotation

Gene Ontology Annotations    

Cellular Component

Objects Annotated

Genes (Rattus norvegicus)
Glrx  (glutaredoxin)
Glrx2  (glutaredoxin 2)


Additional Information