RGD Reference Report - Phosphatidylserine specific binding protein in rat brain: purification and characterization. - Rat Genome Database

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Phosphatidylserine specific binding protein in rat brain: purification and characterization.

Authors: Nakaoka, T  Kojima, N  Hamamoto, T  Kurosawa, N  Lee, YC  Kawasaki, H  Suzuki, K  Tsuji, S 
Citation: Nakaoka T, etal., J Biochem. 1993 Oct;114(4):449-52.
RGD ID: 9685327
Pubmed: (View Article at PubMed) PMID:8276751

A calcium-independent phosphatidylserine specific binding protein detected on liposome blotting analysis was purified from rat brain and revealed to be identical to myristoylated, alanine-rich C kinase substrate (MARCKS). MARCKS specifically binds to phosphatidylserine but not phosphatidylcholine. The binding of MARCKS to phosphatidylserine was abolished on protein kinase C-dependent phosphorylation. Since bacterially expressed MARCKS also specifically binds to phosphatidylserine, myristoylation of the N-terminal glycine seems not to be essential for the binding of MARCKS to phosphatidylserine. These data suggest that phosphatidylserine is a membranous target molecule of MARCKS.

Annotation

Gene Ontology Annotations    

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Marcks  (myristoylated alanine rich protein kinase C substrate)


Additional Information