RGD Reference Report - Gene knockdown studies revealed CCDC50 as a candidate gene in mantle cell lymphoma and chronic lymphocytic leukemia. - Rat Genome Database

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Gene knockdown studies revealed CCDC50 as a candidate gene in mantle cell lymphoma and chronic lymphocytic leukemia.

Authors: Farfsing, A  Engel, F  Seiffert, M  Hartmann, E  Ott, G  Rosenwald, A  Stilgenbauer, S  Dohner, H  Boutros, M  Lichter, P  Pscherer, A 
Citation: Farfsing A, etal., Leukemia. 2009 Nov;23(11):2018-26. doi: 10.1038/leu.2009.144. Epub 2009 Jul 30.
RGD ID: 9685139
Pubmed: PMID:19641524   (View Abstract at PubMed)
DOI: DOI:10.1038/leu.2009.144   (Journal Full-text)

The two B-cell non-Hodgkin's lymphoma entities, chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), show recurrent chromosomal gains of 3q25-q29, 12q13-q14 and 18q21-q22. The pathomechanisms affected by these aberrations are not understood. The aim of this study was to identify genes, located within these gained regions, which control cell death and cell survival of MCL and CLL cancer cells. Blood samples collected from 18 patients with CLL and 6 patients with MCL, as well as 6 cell lines representing both malignancies were analyzed by gene expression profiling. By a comparison of genomic DNA and gene expression, 72 candidate genes were identified. We performed a limited RNA interference screening with these candidates to identify genes affecting cell survival. CCDC50 (coiled coil domain containing protein 50), SERPINI2 and SMARCC2 mediated a reduction of cell viability in primary CLL cells as well as in cell lines. Gene knockdown and a nuclear factor kappa B (NFkappaB) reporter gene assay revealed that CCDC50 is required for survival in MCL and CLL cells and controls NFkappaB signaling.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Objects Annotated

Genes (Rattus norvegicus)
Ccdc50  (coiled-coil domain containing 50)

Genes (Mus musculus)
Ccdc50  (coiled-coil domain containing 50)

Genes (Homo sapiens)
CCDC50  (coiled-coil domain containing 50)


Additional Information