RGD Reference Report - Association study of polymorphisms rs4552569 and rs17095830 and the risk of ankylosing spondylitis in a Taiwanese population. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Association study of polymorphisms rs4552569 and rs17095830 and the risk of ankylosing spondylitis in a Taiwanese population.

Authors: Wei, JC  Hsu, YW  Hung, KS  Wong, RH  Huang, CH  Liu, YT  Guo, YC  Ikegawa, S  Chang, WC 
Citation: Wei JC, etal., PLoS One. 2013;8(1):e52801. doi: 10.1371/journal.pone.0052801. Epub 2013 Jan 4.
RGD ID: 9684849
Pubmed: PMID:23308121   (View Abstract at PubMed)
PMCID: PMC3537770   (View Article at PubMed Central)
DOI: DOI:10.1371/journal.pone.0052801   (Journal Full-text)

Ankylosing spondylitis (AS) is a chronic inflammation of the sacroiliac joints, spine and peripheral joints. However, the development of anklosing spondylitis is unclear. Human leukocyte antigens HLA-B27 and ERAP1 have been widely reported to be associated with AS susceptibility. A recent genome-wide association study (GWAS) showed that two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569) and within ANO6 at 12q12 (rs17095830) contribute to the risk of AS in Han Chinese. In this study, we enrolled 475 AS patients and 475 healthy subjects to assess whether these genetic variations contribute to the susceptibility and the severity of AS in the Taiwanese population. The correlation between genetic polymorphisms, AS activity indexes, (namely, BASDAI, BASFI and BAS-G) and AS complications (uveitis and inflammatory bowel disease) were tested using the markers, rs4552569 and rs17095830. Although no association between rs4552569/rs17095830 genetic polymorphisms and AS susceptibility/severity was found, a significant association between rs17095830 and inflammatory bowel disease was observed in a Taiwanese population.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ANO6Humanankylosing spondylitis severityIAGP DNA:SNP: :rs17095830(human)RGD 
Ano6Ratankylosing spondylitis severityISOANO6 (Homo sapiens)DNA:SNP: :rs17095830(human)RGD 
Ano6Mouseankylosing spondylitis severityISOANO6 (Homo sapiens)DNA:SNP: :rs17095830(human)RGD 
ANO6Humaninflammatory bowel disease  IAGP associated with Spondylitis more ...RGD 
Ano6Ratinflammatory bowel disease  ISOANO6 (Homo sapiens)associated with Spondylitis more ...RGD 
Ano6Mouseinflammatory bowel disease  ISOANO6 (Homo sapiens)associated with Spondylitis more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ano6  (anoctamin 6)

Genes (Mus musculus)
Ano6  (anoctamin 6)

Genes (Homo sapiens)
ANO6  (anoctamin 6)


Additional Information