RGD Reference Report - DNMT3B (C46359T) polymorphisms and immunoexpression of DNMT3b and DNMT1 proteins in oral lichen planus. - Rat Genome Database

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DNMT3B (C46359T) polymorphisms and immunoexpression of DNMT3b and DNMT1 proteins in oral lichen planus.

Authors: Fonseca-Silva, T  Oliveira, MV  Fraga, CA  Farias, LC  Gomes, EP  Barros, LO  Roy, A  Santiago Gomez, R  Paula, AM  Guimaraes, AL 
Citation: Fonseca-Silva T, etal., Pathobiology. 2012;79(1):18-23. doi: 10.1159/000330171. Epub 2012 Jan 12.
RGD ID: 9589075
Pubmed: PMID:22236544   (View Abstract at PubMed)
DOI: DOI:10.1159/000330171   (Journal Full-text)

OBJECTIVE: To investigate the DNMT3B (C46359T) polymorphism and immunoexpression of DNMT3b and DNMT1 in oral lichen planus (OLP) compared to a control group. METHODS: We aimed to investigate the DNMT3B (C46359T) polymorphism and immunoexpression of DNMT3b and DNMT1 in OLP (n = 32), comparing it with oral mucosa (control; n = 24). The DNMT3B (C46359T) polymorphism was analyzed using the RFLP-PCR and DNMT1, and DNMT3a proteins were identified using immunohistochemistry. We also compared the DNMT3B expression in OLP and oral inflammatory fibrous hyperplasia (OIFH), another oral inflammatory disease. Differences between the groups were determined by specific statistical analyses. RESULTS: The CT genotype of DNMT3B was associated with OLP development (p = 0.012). Increased expression of DNMT3B and DNMT1 was observed in OLP compared to the control group (p = 0.014 and p = 0.001, respectively). A significant increase in DNMT3B protein levels was observed in the genotype CT in DNMT3B (C46359T) polymorphisms (p = 0.045). No DNMT3B expression differences between OLP and OIFH were observed. CONCLUSIONS: Our data show that the DNMT3B (C46359T) polymorphism is associated with OLP development. Furthermore, increased expression of the enzyme DNMT3B, an epigenetic-associated protein, is present in OLP.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Oral Lichen Planus  IEP 9589075; 9589075protein:increased expression:mouth mucosa:RGD 
Oral Lichen Planus susceptibilityIAGP 9589075DNA:polymorphism: :C46359T(human)RGD 
Oral Lichen Planus  ISODNMT1 (Homo sapiens)9589075; 9589075protein:increased expression:mouth mucosa:RGD 
Oral Lichen Planus susceptibilityISODNMT3B (Homo sapiens)9589075; 9589075DNA:polymorphism: :C46359T(human)RGD 
Oral Lichen Planus  ISODNMT3B (Homo sapiens)9589075; 9589075protein:increased expression:mouth mucosa:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Dnmt1  (DNA methyltransferase 1)
Dnmt3b  (DNA methyltransferase 3 beta)

Genes (Mus musculus)
Dnmt1  (DNA methyltransferase 1)
Dnmt3b  (DNA methyltransferase 3B)

Genes (Homo sapiens)
DNMT1  (DNA methyltransferase 1)
DNMT3B  (DNA methyltransferase 3 beta)


Additional Information