RGD Reference Report - Electroconvulsive seizures regulates the Brd1 gene in the frontal cortex and hippocampus of the adult rat. - Rat Genome Database

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Electroconvulsive seizures regulates the Brd1 gene in the frontal cortex and hippocampus of the adult rat.

Authors: Fryland, T  Elfving, B  Christensen, JH  Mors, O  Wegener, G  Borglum, AD 
Citation: Fryland T, etal., Neurosci Lett. 2012 May 10;516(1):110-3.
RGD ID: 9586108
Pubmed: PMID:22675730   (View Abstract at PubMed)

Depressive disorders represent a significant health concern as they are associated with high social and physical dysfunction and increased risk for suicide. Electroconvulsive therapy (ECT) is the most effective treatment for patients with drug-resistant severe depressive disorders. However, the underlying biological mechanisms of ECT are not well characterized. In particular, the regulation of transcription factors upon ECT has only just started to be unveiled. The schizophrenia and bipolar disorder associated bromodomain containing 1 (BRD1) gene is important for the acetylation of histone H3K14 and holds a key role in normal embryonic development and survival. In this study, we have measured Brd1 mRNA in the hippocampus and the frontal cortex of male Sprague-Dawley rats upon acute and repeated electroconvulsive seizures (ECS) over a period of 10 days. We found an increase in the general expression of Brd1 mRNA in the hippocampus after repeated ECS compared to sham (F = 8.108, P = 0.003). Furthermore, we provide evidence suggesting a decrease in the expression of the Brd1 mRNA variant comprising an extended version of exon 7 (Brd1-L) in the frontal cortex after repeated ECS compared to sham (F = 6.225, P = 0.023). These findings indicate that regulation of the Brd1 gene is part of the biological response to ECS and that splice variants are induced differentially in different brain regions.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
visual epilepsy  ISOBrd1 (Rattus norvegicus)9586108; 9586108 RGD 
visual epilepsy  IEP 9586108 RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to electrical stimulus  IEP 9586108 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Brd1  (bromodomain containing 1)

Genes (Mus musculus)
Brd1  (bromodomain containing 1)

Genes (Homo sapiens)
BRD1  (bromodomain containing 1)


Additional Information