RGD Reference Report - Alterations of serum selenium, zinc, copper, and iron concentrations and some related antioxidant enzyme activities in patients with cutaneous leishmaniasis. - Rat Genome Database

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Alterations of serum selenium, zinc, copper, and iron concentrations and some related antioxidant enzyme activities in patients with cutaneous leishmaniasis.

Authors: Kocyigit, A  Erel, O  Gurel, MS  Avci, S  Aktepe, N 
Citation: Kocyigit A, etal., Biol Trace Elem Res. 1998 Dec;65(3):271-81.
RGD ID: 9479188
Pubmed: PMID:9892499   (View Abstract at PubMed)
DOI: DOI:10.1007/BF02789102   (Journal Full-text)

The aim of this study was to measure the alterations in serum selenium (Se), copper (Cu), zinc (Zn), and iron (Fe) concentrations and their carrier proteins, ceruloplasmin (Cp), transferrin (Tf) albumin, and related antioxidant enzyme activities, erythrocyte Cu-Zn superoxide dismutase (Cu-Zn SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activities in patients with cutaneous leishmaniasis (CL). Erythrocyte Cu-Zn SOD activities, serum Cu concentrations, and Cp levels were found to be significantly higher in the patients group than those of controls. However, GSH-Px and CAT activities and Se, Zn, Fe, and Tf levels were lower in patients than in the control subjects. There were positive important correlation's between Cu-Zn SOD and Cp, Cu-Zn SOD and Cu, Cp and Cu, GSH-Px and Se, and Fe and CAT in the patients group. Our results showed that serum essential trace elements Se, Zn, Cu, and Fe concentrations and their related enzymes Cu-Zn SOD, GSH-Px, and CAT activities change in CL patients. The changes may be a part of defense strategies of organism and are induced by the hormonelike substances.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CATHumancutaneous leishmaniasis  IEP protein:decreased activity:erythrocyte:RGD 
CatRatcutaneous leishmaniasis  ISOCAT (Homo sapiens)protein:decreased activity:erythrocyte:RGD 
CatMousecutaneous leishmaniasis  ISOCAT (Homo sapiens)protein:decreased activity:erythrocyte:RGD 
SOD1Humancutaneous leishmaniasis  IEP protein:increased activity:erythrocyte:RGD 
Sod1Ratcutaneous leishmaniasis  ISOSOD1 (Homo sapiens)protein:increased activity:erythrocyte:RGD 
Sod1Mousecutaneous leishmaniasis  ISOSOD1 (Homo sapiens)protein:increased activity:erythrocyte:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cat  (catalase)
Sod1  (superoxide dismutase 1)

Genes (Mus musculus)
Cat  (catalase)
Sod1  (superoxide dismutase 1, soluble)

Genes (Homo sapiens)
CAT  (catalase)
SOD1  (superoxide dismutase 1)


Additional Information