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Every amino acid matters: essential contributions of histone variants to mammalian development and disease.

Authors: Maze, I  Noh, KM  Soshnev, AA  Allis, CD 
Citation: Maze I, etal., Nat Rev Genet. 2014 Apr;15(4):259-71. doi: 10.1038/nrg3673. Epub 2014 Mar 11.
Pubmed: (View Article at PubMed) PMID:24614311
DOI: Full-text: DOI:10.1038/nrg3673

Despite a conserved role for histones as general DNA packaging agents, it is now clear that another key function of these proteins is to confer variations in chromatin structure to ensure dynamic patterns of transcriptional regulation in eukaryotes. The incorporation of histone variants is particularly important to this process. Recent knockdown and knockout studies in various cellular systems, as well as direct mutational evidence from human cancers, now suggest a crucial role for histone variant regulation in processes as diverse as differentiation and proliferation, meiosis and nuclear reprogramming. In this Review, we provide an overview of histone variants in the context of their unique functions during mammalian germ cell and embryonic development, and examine the consequences of aberrant histone variant regulation in human disease.


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RGD Object Information
RGD ID: 9075965
Created: 2014-08-25
Species: All species
Last Modified: 2014-08-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.