RGD Reference Report - Quantitative Trait Loci Influencing Abdominal Fat Deposition and Functional Variability of the HPA Axis in the Rat. - Rat Genome Database

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Quantitative Trait Loci Influencing Abdominal Fat Deposition and Functional Variability of the HPA Axis in the Rat.

Authors: Marissal-Arvy, N  Helies, JM  Tridon, C  Moisan, MP  Mormede, P 
Citation: Marissal-Arvy N, etal., Horm Metab Res. 2014 Jul 8.
RGD ID: 8694157
Pubmed: PMID:25003539   (View Abstract at PubMed)
DOI: DOI:10.1055/s-0034-1383574   (Journal Full-text)

With the aim to reveal common genomic regions influencing phenotypes related to HPA axis function and metabolism, we did a quantitative trait loci (QTL) study in a F2 population obtained from the cross-breeding between 2 contrasted rat strains, LOU/C and Fischer 344. QTL determining phenotypes related first to corticotropic function were searched: plasma corticosterone (Cort) in control and stress conditions, after a dexamethasone suppression treatment (glucocorticoid receptor related-effect), and mineralocorticoid receptor-mediated urinary response to aldosterone. Then, phenotypes related to metabolism were studied on the same animals: body composition, basal and post-insulin plasma glucose, plasma free fatty acids, leptin, and insulin. Finally, we analyzed the overlapping regions between these QTL and looked for candidate genes within these regions. The gene NR3C1 encoding the glucocorticoid receptor was confirmed to be central in the link between hypothalamic-pituitary-adrenal (HPA) axis function and fat deposition, and its metabolic consequences. Among the other candidate genes detected, most contain a glucocorticoid responsive element, strengthening our hypothesis of common genetic determinism between HPA axis and metabolism.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Abfw1Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Abfw2Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Abfw3Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Abfw4Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Abfw5Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Abfw6Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Abfw7Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Abfw8Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw147Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw148Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw149Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw150Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw151Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw152Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw153Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw154Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw155Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw156Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw157Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw158Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw159Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw160Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw161Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw162Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw163Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw164Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw165Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw166Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw167Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw168Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw169Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw170Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw171Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Bw172Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Epfw10Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Epfw11Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Epfw12Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Epfw6Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Epfw7Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Epfw8Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Epfw9Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Scfw1Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Scfw2Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Scfw3Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Scfw4Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Scfw5Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Scfw6Ratabdominal obesity-metabolic syndrome  IAGP  RGD 
Slep10Ratdisease of metabolism  IAGP  RGD 
Slep11Ratdisease of metabolism  IAGP  RGD 
Slep12Ratdisease of metabolism  IAGP  RGD 
Slep13Ratdisease of metabolism  IAGP  RGD 
Gluco65Ratglucose metabolism disease  IAGP  RGD 
Gluco66Ratglucose metabolism disease  IAGP  RGD 
Gluco67Ratglucose metabolism disease  IAGP  RGD 
Gluco68Ratglucose metabolism disease  IAGP  RGD 
Insul23Ratglucose metabolism disease  IAGP  RGD 
Insul24Ratglucose metabolism disease  IAGP  RGD 
Insul25Ratglucose metabolism disease  IAGP  RGD 
Insul26Ratglucose metabolism disease  IAGP  RGD 
Insul27Ratglucose metabolism disease  IAGP  RGD 
Insul28Ratglucose metabolism disease  IAGP  RGD 
Insul29Ratglucose metabolism disease  IAGP  RGD 
Insul30Ratglucose metabolism disease  IAGP  RGD 
Insul31Ratglucose metabolism disease  IAGP  RGD 
Insul32Ratglucose metabolism disease  IAGP  RGD 
Insglur3RatInsulin Resistance  IAGP  RGD 
Insglur4RatInsulin Resistance  IAGP  RGD 
Insglur5RatInsulin Resistance  IAGP  RGD 
Insglur6RatInsulin Resistance  IAGP  RGD 
Insglur7RatInsulin Resistance  IAGP  RGD 
Insglur8RatInsulin Resistance  IAGP  RGD 
Insglur9RatInsulin Resistance  IAGP  RGD 
Scort10Ratlipid metabolism disorder  IAGP  RGD 
Scort11Ratlipid metabolism disorder  IAGP  RGD 
Scort12Ratlipid metabolism disorder  IAGP  RGD 
Scort13Ratlipid metabolism disorder  IAGP  RGD 
Scort14Ratlipid metabolism disorder  IAGP  RGD 
Scort15Ratlipid metabolism disorder  IAGP  RGD 
Scort16Ratlipid metabolism disorder  IAGP  RGD 
Scort17Ratlipid metabolism disorder  IAGP  RGD 
Scort18Ratlipid metabolism disorder  IAGP  RGD 
Scort19Ratlipid metabolism disorder  IAGP  RGD 
Scort20Ratlipid metabolism disorder  IAGP  RGD 
Scort21Ratlipid metabolism disorder  IAGP  RGD 
Scort22Ratlipid metabolism disorder  IAGP  RGD 
Scort3Ratlipid metabolism disorder  IAGP  RGD 
Scort4Ratlipid metabolism disorder  IAGP  RGD 
Scort5Ratlipid metabolism disorder  IAGP  RGD 
Scort6Ratlipid metabolism disorder  IAGP  RGD 
Scort7Ratlipid metabolism disorder  IAGP  RGD 
Scort8Ratlipid metabolism disorder  IAGP  RGD 
Scort9Ratlipid metabolism disorder  IAGP  RGD 
Sffal3Ratlipid metabolism disorder  IAGP  RGD 
Sffal4Ratlipid metabolism disorder  IAGP  RGD 
Sffal5Ratlipid metabolism disorder  IAGP  RGD 
Sffal6Ratlipid metabolism disorder  IAGP  RGD 
Sffal7Ratlipid metabolism disorder  IAGP  RGD 
Sffal8Ratlipid metabolism disorder  IAGP  RGD 
Uminl1RatWater-Electrolyte Imbalance  IAGP  RGD 
Uminl2RatWater-Electrolyte Imbalance  IAGP  RGD 
Uminl3RatWater-Electrolyte Imbalance  IAGP  RGD 
Uminl4RatWater-Electrolyte Imbalance  IAGP  RGD 
Uminl5RatWater-Electrolyte Imbalance  IAGP  RGD 
Abfw1RatWeight Gain  IAGP  RGD 
Abfw2RatWeight Gain  IAGP  RGD 
Abfw3RatWeight Gain  IAGP  RGD 
Abfw4RatWeight Gain  IAGP  RGD 
Abfw5RatWeight Gain  IAGP  RGD 
Abfw6RatWeight Gain  IAGP  RGD 
Abfw7RatWeight Gain  IAGP  RGD 
Abfw8RatWeight Gain  IAGP  RGD 
Bw147RatWeight Gain  IAGP  RGD 
Bw148RatWeight Gain  IAGP  RGD 
Bw149RatWeight Gain  IAGP  RGD 
Bw150RatWeight Gain  IAGP  RGD 
Bw151RatWeight Gain  IAGP  RGD 
Bw152RatWeight Gain  IAGP  RGD 
Bw153RatWeight Gain  IAGP  RGD 
Bw154RatWeight Gain  IAGP  RGD 
Bw155RatWeight Gain  IAGP  RGD 
Bw156RatWeight Gain  IAGP  RGD 
Bw157RatWeight Gain  IAGP  RGD 
Bw158RatWeight Gain  IAGP  RGD 
Bw159RatWeight Gain  IAGP  RGD 
Bw160RatWeight Gain  IAGP  RGD 
Bw161RatWeight Gain  IAGP  RGD 
Bw162RatWeight Gain  IAGP  RGD 
Bw163RatWeight Gain  IAGP  RGD 
Bw164RatWeight Gain  IAGP  RGD 
Bw165RatWeight Gain  IAGP  RGD 
Bw166RatWeight Gain  IAGP  RGD 
Bw167RatWeight Gain  IAGP  RGD 
Bw168RatWeight Gain  IAGP  RGD 
Bw169RatWeight Gain  IAGP  RGD 
Bw170RatWeight Gain  IAGP  RGD 
Bw171RatWeight Gain  IAGP  RGD 
Bw172RatWeight Gain  IAGP  RGD 
Epfw10RatWeight Gain  IAGP  RGD 
Epfw11RatWeight Gain  IAGP  RGD 
Epfw12RatWeight Gain  IAGP  RGD 
Epfw6RatWeight Gain  IAGP  RGD 
Epfw7RatWeight Gain  IAGP  RGD 
Epfw8RatWeight Gain  IAGP  RGD 
Epfw9RatWeight Gain  IAGP  RGD 
Scfw1RatWeight Gain  IAGP  RGD 
Scfw2RatWeight Gain  IAGP  RGD 
Scfw3RatWeight Gain  IAGP  RGD 
Scfw4RatWeight Gain  IAGP  RGD 
Scfw5RatWeight Gain  IAGP  RGD 
Scfw6RatWeight Gain  IAGP  RGD 
Slep10RatWeight Gain  IAGP  RGD 
Slep11RatWeight Gain  IAGP  RGD 
Slep12RatWeight Gain  IAGP  RGD 
Slep13RatWeight Gain  IAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Uminl1Ratabnormal urine homeostasis  IDA  RGD 
Uminl2Ratabnormal urine homeostasis  IDA  RGD 
Uminl3Ratabnormal urine homeostasis  IDA  RGD 
Uminl4Ratabnormal urine homeostasis  IDA  RGD 
Uminl5Ratabnormal urine homeostasis  IDA  RGD 
Abfw1Ratincreased body weight  IDA  RGD 
Abfw2Ratincreased body weight  IDA  RGD 
Abfw3Ratincreased body weight  IDA  RGD 
Abfw4Ratincreased body weight  IDA  RGD 
Abfw5Ratincreased body weight  IDA  RGD 
Abfw6Ratincreased body weight  IDA  RGD 
Abfw7Ratincreased body weight  IDA  RGD 
Abfw8Ratincreased body weight  IDA  RGD 
Bw147Ratincreased body weight  IDA  RGD 
Bw148Ratincreased body weight  IDA  RGD 
Bw149Ratincreased body weight  IDA  RGD 
Bw150Ratincreased body weight  IDA  RGD 
Bw151Ratincreased body weight  IDA  RGD 
Bw152Ratincreased body weight  IDA  RGD 
Bw153Ratincreased body weight  IDA  RGD 
Bw154Ratincreased body weight  IDA  RGD 
Bw155Ratincreased body weight  IDA  RGD 
Bw156Ratincreased body weight  IDA  RGD 
Bw157Ratincreased body weight  IDA  RGD 
Bw158Ratincreased body weight  IDA  RGD 
Bw159Ratincreased body weight  IDA  RGD 
Bw160Ratincreased body weight  IDA  RGD 
Bw161Ratincreased body weight  IDA  RGD 
Bw162Ratincreased body weight  IDA  RGD 
Bw163Ratincreased body weight  IDA  RGD 
Bw164Ratincreased body weight  IDA  RGD 
Bw165Ratincreased body weight  IDA  RGD 
Bw166Ratincreased body weight  IDA  RGD 
Bw167Ratincreased body weight  IDA  RGD 
Bw168Ratincreased body weight  IDA  RGD 
Bw169Ratincreased body weight  IDA  RGD 
Bw170Ratincreased body weight  IDA  RGD 
Bw171Ratincreased body weight  IDA  RGD 
Bw172Ratincreased body weight  IDA  RGD 
Epfw10Ratincreased body weight  IDA  RGD 
Epfw11Ratincreased body weight  IDA  RGD 
Epfw12Ratincreased body weight  IDA  RGD 
Epfw6Ratincreased body weight  IDA  RGD 
Epfw7Ratincreased body weight  IDA  RGD 
Epfw8Ratincreased body weight  IDA  RGD 
Epfw9Ratincreased body weight  IDA  RGD 
Scfw1Ratincreased body weight  IDA  RGD 
Scfw2Ratincreased body weight  IDA  RGD 
Scfw3Ratincreased body weight  IDA  RGD 
Scfw4Ratincreased body weight  IDA  RGD 
Scfw5Ratincreased body weight  IDA  RGD 
Scfw6Ratincreased body weight  IDA  RGD 
Scort10Ratincreased circulating corticosterone level  IDA  RGD 
Scort11Ratincreased circulating corticosterone level  IDA  RGD 
Scort12Ratincreased circulating corticosterone level  IDA  RGD 
Scort13Ratincreased circulating corticosterone level  IDA  RGD 
Scort14Ratincreased circulating corticosterone level  IDA  RGD 
Scort15Ratincreased circulating corticosterone level  IDA  RGD 
Scort16Ratincreased circulating corticosterone level  IDA  RGD 
Scort17Ratincreased circulating corticosterone level  IDA  RGD 
Scort18Ratincreased circulating corticosterone level  IDA  RGD 
Scort19Ratincreased circulating corticosterone level  IDA  RGD 
Scort20Ratincreased circulating corticosterone level  IDA  RGD 
Scort21Ratincreased circulating corticosterone level  IDA  RGD 
Scort22Ratincreased circulating corticosterone level  IDA  RGD 
Scort3Ratincreased circulating corticosterone level  IDA  RGD 
Scort4Ratincreased circulating corticosterone level  IDA  RGD 
Scort5Ratincreased circulating corticosterone level  IDA  RGD 
Scort6Ratincreased circulating corticosterone level  IDA  RGD 
Scort7Ratincreased circulating corticosterone level  IDA  RGD 
Scort8Ratincreased circulating corticosterone level  IDA  RGD 
Scort9Ratincreased circulating corticosterone level  IDA  RGD 
Sffal3Ratincreased circulating free fatty acids level  IDA  RGD 
Sffal4Ratincreased circulating free fatty acids level  IDA  RGD 
Sffal5Ratincreased circulating free fatty acids level  IDA  RGD 
Sffal6Ratincreased circulating free fatty acids level  IDA  RGD 
Sffal7Ratincreased circulating free fatty acids level  IDA  RGD 
Sffal8Ratincreased circulating free fatty acids level  IDA  RGD 
Gluco65Ratincreased circulating glucose level  IDA  RGD 
Gluco66Ratincreased circulating glucose level  IDA  RGD 
Gluco67Ratincreased circulating glucose level  IDA  RGD 
Gluco68Ratincreased circulating glucose level  IDA  RGD 
Insul23Ratincreased circulating insulin level  IDA  RGD 
Insul24Ratincreased circulating insulin level  IDA  RGD 
Insul25Ratincreased circulating insulin level  IDA  RGD 
Insul26Ratincreased circulating insulin level  IDA  RGD 
Insul27Ratincreased circulating insulin level  IDA  RGD 
Insul28Ratincreased circulating insulin level  IDA  RGD 
Insul29Ratincreased circulating insulin level  IDA  RGD 
Insul30Ratincreased circulating insulin level  IDA  RGD 
Insul31Ratincreased circulating insulin level  IDA  RGD 
Insul32Ratincreased circulating insulin level  IDA  RGD 
Slep10Ratincreased circulating leptin level  IDA  RGD 
Slep11Ratincreased circulating leptin level  IDA  RGD 
Slep12Ratincreased circulating leptin level  IDA  RGD 
Slep13Ratincreased circulating leptin level  IDA  RGD 
Insglur3Ratinsulin resistance  IDA  RGD 
Insglur4Ratinsulin resistance  IAGP  RGD 
Insglur5Ratinsulin resistance  IDA  RGD 
Insglur6Ratinsulin resistance  IDA  RGD 
Insglur7Ratinsulin resistance  IDA  RGD 
Insglur8Ratinsulin resistance  IDA  RGD 
Insglur9Ratinsulin resistance  IDA  RGD 
Objects Annotated

Abfw1  (Abdominal fat weight QTL 1)
Abfw2  (Abdominal fat weight QTL 2)
Abfw3  (Abdominal fat weight QTL 3)
Abfw4  (Abdominal fat weight QTL 4)
Abfw5  (Abdominal fat weight QTL 5)
Abfw6  (Abdominal fat weight QTL 6)
Abfw7  (Abdominal fat weight QTL 7)
Abfw8  (Abdominal fat weight QTL 8)
Bw147  (Body weight QTL 147)
Bw148  (Body weight QTL 148)
Bw149  (Body weight QTL 149)
Bw150  (Body weight QTL 150)
Bw151  (Body weight QTL 151)
Bw152  (Body weight QTL 152)
Bw153  (Body weight QTL 153)
Bw154  (Body weight QTL 154)
Bw155  (Body weight QTL 155)
Bw156  (Body weight QTL 156)
Bw157  (Body weight QTL 157)
Bw158  (Body weight QTL 158)
Bw159  (Body weight QTL 159)
Bw160  (Body weight QTL 160)
Bw161  (Body weight QTL 161)
Bw162  (Body weight QTL 162)
Bw163  (Body weight QTL 163)
Bw164  (Body weight QTL 164)
Bw165  (Body weight QTL 165)
Bw166  (Body weight QTL 166)
Bw167  (Body weight QTL 167)
Bw168  (Body weight QTL 168)
Bw169  (Body weight QTL 169)
Bw170  (Body weight QTL 170)
Bw171  (Body weight QTL 171)
Bw172  (Body weight QTL 172)
Epfw10  (Epididymal fat weight QTL 10)
Epfw11  (Epididymal fat weight QTL 11)
Epfw12  (Epididymal fat weight QTL 12)
Epfw6  (Epididymal fat weight QTL 6)
Epfw7  (Epididymal fat weight QTL 7)
Epfw8  (Epididymal fat weight QTL 8)
Epfw9  (Epididymal fat weight QTL 9)
Gluco65  (Glucose level QTL 65)
Gluco66  (Glucose level QTL 66)
Gluco67  (Glucose level QTL 67)
Gluco68  (Glucose level QTL 68)
Insglur3  (Insulin/glucose ratio QTL 3)
Insglur4  (Insulin/glucose ratio QTL 4)
Insglur5  (Insulin/glucose ratio QTL 5)
Insglur6  (Insulin/glucose ratio QTL 6)
Insglur7  (Insulin/glucose ratio QTL 7)
Insglur8  (Insulin/glucose ratio QTL 8)
Insglur9  (Insulin/glucose ratio QTL 9)
Insul23  (Insulin level QTL 23)
Insul24  (Insulin level QTL 24)
Insul25  (Insulin level QTL 25)
Insul26  (Insulin level QTL 26)
Insul27  (Insulin level QTL 27)
Insul28  (Insulin level QTL 28)
Insul29  (Insulin level QTL 29)
Insul30  (Insulin level QTL 30)
Insul31  (Insulin level QTL 31)
Insul32  (Insulin level QTL 32)
Scfw1  (Subcutaneous fat weight QTL 1)
Scfw2  (Subcutaneous fat weight QTL 2)
Scfw3  (Subcutaneous fat weight QTL 3)
Scfw4  (Subcutaneous fat weight QTL 4)
Scfw5  (Subcutaneous fat weight QTL 5)
Scfw6  (Subcutaneous fat weight QTL 6)
Scort10  (Serum corticosterone level QTL 10)
Scort11  (Serum corticosterone level QTL 11)
Scort12  (Serum corticosterone level QTL 12)
Scort13  (Serum corticosterone level QTL 13)
Scort14  (Serum corticosterone level QTL 14)
Scort15  (Serum corticosterone level QTL 15)
Scort16  (Serum corticosterone level QTL 16)
Scort17  (Serum corticosterone level QTL 17)
Scort18  (Serum corticosterone level QTL 18)
Scort19  (Serum corticosterone level QTL 19)
Scort20  (Serum corticosterone level QTL 20)
Scort21  (Serum corticosterone level QTL 21)
Scort22  (Serum corticosterone level QTL 22)
Scort3  (Serum corticosterone level QTL 3)
Scort4  (Serum corticosterone level QTL 4)
Scort5  (Serum corticosterone level QTL 5)
Scort6  (Serum corticosterone level QTL 6)
Scort7  (Serum corticosterone level QTL 7)
Scort8  (Serum corticosterone level QTL 8)
Scort9  (Serum corticosterone level QTL 9)
Sffal3  (Serum free fatty acids level QTL 3)
Sffal4  (Serum free fatty acids level QTL 4)
Sffal5  (Serum free fatty acids level QTL 5)
Sffal6  (Serum free fatty acids level QTL 6)
Sffal7  (Serum free fatty acids level QTL 7)
Sffal8  (Serum free fatty acids level QTL 8)
Slep10  (Serum leptin concentration QTL 10)
Slep11  (Serum leptin concentration QTL 11)
Slep12  (Serum leptin concentration QTL 12)
Slep13  (Serum leptin concentration QTL 13)
Uminl1  (Urine mineral level QTL 1)
Uminl2  (Urine mineral level QTL 2)
Uminl3  (Urine mineral level QTL 3)
Uminl4  (Urine mineral level QTL 4)
Uminl5  (Urine mineral level QTL 5)

F344/IcoCrlf  (NA)
LOU/NimrOlaHsd  (Louvain)

Additional Information