RGD Reference Report - Pin1 inhibition activates cyclin D and produces neurodegenerative pathology. - Rat Genome Database

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Pin1 inhibition activates cyclin D and produces neurodegenerative pathology.

Authors: Atabay, KD  Karabay, A 
Citation: Atabay KD and Karabay A, J Neurochem. 2012 Feb;120(3):430-9. doi: 10.1111/j.1471-4159.2011.07259.x. Epub 2011 May 5.
RGD ID: 8693576
Pubmed: PMID:21443524   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1471-4159.2011.07259.x   (Journal Full-text)

Abnormal cell cycle events are increasingly becoming important attributes of neurodegenerative pathology. Pin1 is a crucial target of neurodegeneration in relation to its functions regarding these abnormal cell cycle events in neurons. Pin1 is majorly involved in many aspects of cell cycle regulation and it has also been suggested to have a neuroprotective function against neurodegenerative pathologies. Oxidative dysregulation of Pin1 affects not only normal tau regulation, eventually causing tangle formation, but also cell cycle regulation in neurons. Presence of cell cycle proteins has been shown in many neurodegenerative diseases. Importantly, many of these proteins have physical interactions with Pin1. Hence, understanding Pin1's role in abnormal cell cycle re-entry is critical in terms of finding new approaches for the future therapeutic options treating neurodegenerative pathologies. Here, we show that inhibition of Pin1 by its selective inhibitor juglone leads to up-regulation of cyclinD1, phospho-tau, and caspase 3, producing apoptosis in cultured rat hippocampal neurons. We also observed axonal retraction with a change in sub-cellular localizations of cyclins. Therefore, Pin1 dysregulation, in relation to its role in cell cycle regulation in neurons, may have profound effects in the progression of neurodegenerative pathology, making it a possible crucial target behind many neurodegenerative diseases.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
negative regulation of neuron apoptotic process  IMP 8693576 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pin1  (peptidylprolyl cis/trans isomerase, NIMA-interacting 1)


Additional Information