RGD Reference Report - [Experimental study on fas expression of spermatogenic cell in male rats induced by fluorine]. - Rat Genome Database
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[Experimental study on fas expression of spermatogenic cell in male rats induced by fluorine].

Authors: Xu, Rui  Shang, Weichao  Liu, Jianmin  Cheng, Xuemin  Ba, Yue  Huang, Hui  Cui, Liuxin 
Citation: Xu R, etal., Wei Sheng Yan Jiu. 2010 May;39(3):358-60.
RGD ID: 8663477
Pubmed: (View Article at PubMed) PMID:20568470

OBJECTIVE: To research the effect of fluorine on the expression of Fas protein, then study the mechanism of male reproductive toxicity induced by fluoride on molecular level.
METHODS: Thirty Wistar male rats were divided into control group, low-dose group and high-dose group. The NaF dosage for every group were 0,2 and 4g/L. The content of NaF in testis was measured by using fluorine selective electrode. Changes of testosterone and Fas protein were observed using the methods of radioimmunoassay, in situ hybridization. In addition, we observed the quality of spermatozoa.
RESULTS: The testis fluoride content of two fluorine treatment groups were higher than that of control group (P < 0.05), and had a dose-dependent effect. The level of testosterone, the number and the livability of the spermatozoon in fluorotic groups were lower than those of control rats (P < 0.05), and the above indexes decreased with the incrase of dosage. The expression of Fas in spermatogenic cells and the sperm aberration of each fluorotic group were higher than control group (P < 0.05), both of them increased with the increase of dosage.
CONCLUSION: Fluorin could reduce the level of serum testosterone, then activated the Fas/FasL system, which caused damage to the reprodutive system.


Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Fas  (Fas cell surface death receptor)

Additional Information