RGD Reference Report - Heat shock protein 70 gene polymorphisms in sudden sensorineural hearing loss. - Rat Genome Database

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Heat shock protein 70 gene polymorphisms in sudden sensorineural hearing loss.

Authors: Chien, CY  Chang, NC  Tai, SY  Wang, LF  Wu, MT  Ho, KY 
Citation: Chien CY, etal., Audiol Neurootol. 2012;17(6):381-5. doi: 10.1159/000341815. Epub 2012 Aug 22.
RGD ID: 8662465
Pubmed: (View Article at PubMed) PMID:22922572
DOI: Full-text: DOI:10.1159/000341815

BACKGROUND: Heat shock proteins protect cells and tissues against different types of damage. Previous studies have revealed that the serum level of heat shock protein 70 (HSP70) increases in sudden sensorineural hearing loss (SSNHL) patients. We hypothesized that genetic variants of the HSP70 gene are associated with susceptibility to SSNHL. METHODS: We conducted a case-control study with 160 SSNHL cases and 178 controls. Three tagging single nucleotide polymorphisms (SNPs) were selected. The genotypes were determined using TaqMan technology. Hardy-Weinberg equilibrium was tested for each SNP, and genetic effects were evaluated according to three inheritance modes. A haplotype analysis was also performed. RESULTS: All three SNPs were in Hardy-Weinberg equilibrium. The CT genotype of rs2075800 exhibited an adjusted odds ratio of 0.59 (95% confidence interval 0.37-0.94; p = 0.027). The T allele of SNP rs2075800 was associated with SSNHL under the dominant model (p = 0.019; odds ratio 0.59). Haplotype analysis of the three SNPs demonstrated that the haplotype TGC (rs2075800/rs1043618/rs2763979) was statistically significant (p = 0.0137). CONCLUSIONS: These results suggest that HSP70 gene polymorphisms influence the susceptibility to the development of SSNHL in the Taiwanese population.

Annotation

Disease Annotations    
Sudden Hearing Loss  (IAGP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Hspa1a  (heat shock protein family A (Hsp70) member 1A)
Hspa1b  (heat shock protein family A (Hsp70) member 1B)
Hspa1l  (heat shock protein family A (Hsp70) member 1 like)

Genes (Mus musculus)
Hspa1a  (heat shock protein 1A)
Hspa1b  (heat shock protein 1B)
Hspa1l  (heat shock protein 1-like)

Genes (Homo sapiens)
HSPA1A  (heat shock protein family A (Hsp70) member 1A)
HSPA1B  (heat shock protein family A (Hsp70) member 1B)
HSPA1L  (heat shock protein family A (Hsp70) member 1 like)


Additional Information