RGD Reference Report - Increased plasma concentrations of complement modulating proteins (C1 inhibitor, C4-binding protein, factor H and factor I) in psoriasis. - Rat Genome Database

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Increased plasma concentrations of complement modulating proteins (C1 inhibitor, C4-binding protein, factor H and factor I) in psoriasis.

Authors: Ohkohchi, K  Torinuki, W  Tagami, H 
Citation: Ohkohchi K, etal., Tohoku J Exp Med. 1988 Apr;154(4):315-21.
RGD ID: 8662318
Pubmed: PMID:2973157   (View Abstract at PubMed)

By using single radial immunodiffusion we measured the plasma levels of four complement modulating proteins, i.e., C1 inhibitor, C4-binding protein, factor H and factor I in 19 psoriatic patients in comparison with those of healthy controls. Except for C1 inhibitor which was only marginally elevated, they were found to be significantly increased in psoriatic patients. When psoriatic patients were classified into subgroups based on the clinical severity, the levels of factor H and those of factor I showed a close positive correlation with the activity and extent of the skin lesions, whereas such clear relationship could not be found with C1 inactivator or with C4-binding protein. These results offer additional support for the hypothesis that the complement system is involved in psoriasis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
psoriasis severityIEP 8662318; 8662318protein:increased expression:plasmaRGD 
psoriasis severityISOCFH (Homo sapiens)8662318; 8662318protein:increased expression:plasmaRGD 
psoriasis severityISOCFI (Homo sapiens)8662318; 8662318protein:increased expression:plasmaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Cfh  (complement factor H)
Cfi  (complement factor I)

Genes (Mus musculus)
Cfh  (complement component factor h)
Cfi  (complement component factor i)

Genes (Homo sapiens)
CFH  (complement factor H)
CFI  (complement factor I)


Additional Information