RGD Reference Report - Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters. - Rat Genome Database

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Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters.

Authors: Zannini, M  Francis-Lang, H  Plachov, D  Di Lauro, R 
Citation: Zannini M, etal., Mol Cell Biol. 1992 Sep;12(9):4230-41.
RGD ID: 8661624
Pubmed: PMID:1508216   (View Abstract at PubMed)
PMCID: PMC360331   (View Article at PubMed Central)

The Pax-8 gene, a member of the murine family of paired box-containing genes (Pax genes), is expressed in adult thyroid and in cultured thyroid cell lines. The Pax-8 protein binds, through its paired domain, to the promoters of thyroglobulin and thyroperoxidase, genes that are exclusively expressed in the thyroid. In both promoters, the binding site of Pax-8 overlaps with that of TTF-1, a homeodomain-containing protein involved in the activation of thyroid-specific transcription. Pax-8 activates transcription from cotransfected thyroperoxidase and thyroglobulin promoters, indicating that it may be involved in the establishment, control, or maintenance of the thyroid-differentiated phenotype. Thus, the promoters of thyroglobulin and thyroperoxidase represent the first identified natural targets for transcriptional activation by a paired domain-containing protein.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Pax8Ratpositive regulation of transcription by RNA polymerase II involved_inIDA PMID:1508216NTNU_SB 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Pax8RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIDA PMID:1508216NTNU_SB 
Pax8RatRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIDA PMID:1508216NTNU_SB 

Objects Annotated

Genes (Rattus norvegicus)
Pax8  (paired box 8)


Additional Information