RGD Reference Report - Variation in the BDNF and NGFB genes in German atopic dermatitis patients. - Rat Genome Database

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Variation in the BDNF and NGFB genes in German atopic dermatitis patients.

Authors: Hoffjan, S  Parwez, Q  Petrasch-Parwez, E  Stemmler, S 
Citation: Hoffjan S, etal., Mol Cell Probes. 2009 Feb;23(1):35-8. doi: 10.1016/j.mcp.2008.10.005. Epub 2008 Nov 11.
RGD ID: 8657067
Pubmed: PMID:19038326   (View Abstract at PubMed)
DOI: DOI:10.1016/j.mcp.2008.10.005   (Journal Full-text)

In humans, atopic dermatitis (AD) is believed to result from a complex interaction between genetic and environmental factors. Based on recent evidence, it has been proposed that neurotrophins play an important role in allergic inflammation. Levels of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in blood have been found to be elevated and correlated positively with disease in AD patients. Therefore, we sought to evaluate the role of nucleotide variation in the NGFB and BDNF genes in relation to the pathogenesis of AD. A functional polymorphism within the BDNF gene (Val66Met) and six selected polymorphisms in the NGFB gene were examined in 361 German AD patients and 325 non-atopic controls. In this cohort, no significant association with AD was detected, refuting the hypothesis that variation in these two neurotrophin genes contributes substantially to AD.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
atopic dermatitis no_associationIAGP 8657067DNA:polymorphism:cds:p.V66M(human)RGD 
atopic dermatitis no_associationISOBDNF (Homo sapiens)8657067; 8657067DNA:polymorphism:cds:p.V66M(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bdnf  (brain-derived neurotrophic factor)

Genes (Mus musculus)
Bdnf  (brain derived neurotrophic factor)

Genes (Homo sapiens)
BDNF  (brain derived neurotrophic factor)


Additional Information