RGD Reference Report - Combined effect of brain-derived neurotrophic factor and LINGO-1 fusion protein on long-term survival of retinal ganglion cells in chronic glaucoma. - Rat Genome Database

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Combined effect of brain-derived neurotrophic factor and LINGO-1 fusion protein on long-term survival of retinal ganglion cells in chronic glaucoma.

Authors: Fu, QL  Li, X  Yip, HK  Shao, Z  Wu, W  Mi, S  So, KF 
Citation: Fu QL, etal., Neuroscience. 2009 Aug 18;162(2):375-82. doi: 10.1016/j.neuroscience.2009.04.075. Epub 2009 May 5.
RGD ID: 8655601
Pubmed: PMID:19422885   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neuroscience.2009.04.075   (Journal Full-text)

Glaucoma is a progressive neuropathy characterized by loss of vision as a result of retinal ganglion cell (RGC) death. There are no effective neuroprotectants to treat this disorder. Brain-derived neurotrophic factor (BDNF) is well known to transiently delay RGC death in ocular hypertensive eyes. The CNS-specific leucine-rich repeat protein LINGO-1 contributes to the negative regulation to some trophic pathways. We thereby examined whether BDNF combined with LINGO-1 antagonists can promote long-term RGC survival after ocular hypertension. In this study, intraocular pressure was elevated in adult rats using an argon laser to photocoagulate the episcleral and limbal veins. BDNF alone shows slight neuroprotection to RGCs after a long-term progress of 4 weeks following the induction of ocular hypertension. However, combination of BDNF and LINGO-1-Fc prevents RGC death in the same condition. We further identified that (1) LINGO-1 was co-expressed with BDNF receptor, TrkB in the RGCs, and (2) BDNF combined with LINGO-1-Fc activated more TrkB in the injured retina compared to BDNF alone. These results indicate that the combination of BDNF with LINGO-1 antagonist can provide long-term protection for RGCs in a chronic ocular hypertension model. TrkB may be the predominant mediator of this neuroprotection.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
glaucoma treatmentIDA 8655601 RGD 
glaucoma treatmentISOBDNF (Homo sapiens)8655601; 8655601 RGD 
glaucoma treatmentIMP 8655601 RGD 
glaucoma treatmentISOLINGO1 (Homo sapiens)8655601; 8655601 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bdnf  (brain-derived neurotrophic factor)
Lingo1  (leucine rich repeat and Ig domain containing 1)

Genes (Mus musculus)
Bdnf  (brain derived neurotrophic factor)
Lingo1  (leucine rich repeat and Ig domain containing 1)

Genes (Homo sapiens)
BDNF  (brain derived neurotrophic factor)
LINGO1  (leucine rich repeat and Ig domain containing 1)


Additional Information