RGD Reference Report - Endogenous and ectopic gland induction by FGF-10. - Rat Genome Database

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Endogenous and ectopic gland induction by FGF-10.

Authors: Govindarajan, V  Ito, M  Makarenkova, HP  Lang, RA  Overbeek, PA 
Citation: Govindarajan V, etal., Dev Biol. 2000 Sep 1;225(1):188-200.
RGD ID: 8554722
Pubmed: PMID:10964474   (View Abstract at PubMed)
DOI: DOI:10.1006/dbio.2000.9812   (Journal Full-text)

FGF-10, a member of the fibroblast growth factor family, is expressed in mesodermally derived cell populations during embryogenesis. During normal ocular development, FGF-10 is expressed in the perioptic mesenchyme adjacent to the Harderian and lacrimal gland primordia. In this report, we provide evidence that FGF-10 is both necessary and sufficient to initiate glandular morphogenesis. Lens-specific expression of FGF-10 was sufficient to induce ectopic ocular glands within the cornea. In addition, lacrimal and Harderian glands were not seen in FGF-10 null fetuses. Based on these results we propose that FGF-10 is an inductive signal that initiates ocular gland morphogenesis.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Fgf10Ratorgan induction acts_upstream_of_or_withinIDA PMID:10964474MGI 

Objects Annotated

Genes (Rattus norvegicus)
Fgf10  (fibroblast growth factor 10)


Additional Information