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Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I.

Authors: Wang, P  Arjona, A  Zhang, Y  Sultana, H  Dai, J  Yang, L  LeBlanc, PM  Doiron, K  Saleh, M  Fikrig, E 
Citation: Wang P, etal., Nat Immunol. 2010 Oct;11(10):912-9. doi: 10.1038/ni.1933. Epub 2010 Sep 5.
Pubmed: (View Article at PubMed) PMID:20818395
DOI: Full-text: DOI:10.1038/ni.1933

Caspase-12 has been shown to negatively modulate inflammasome signaling during bacterial infection. Its function in viral immunity, however, has not been characterized. We now report an important role for caspase-12 in controlling viral infection via the pattern-recognition receptor RIG-I. After challenge with West Nile virus (WNV), caspase-12-deficient mice had greater mortality, higher viral burden and defective type I interferon response compared with those of challenged wild-type mice. In vitro studies of primary neurons and mouse embryonic fibroblasts showed that caspase-12 positively modulated the production of type I interferon by regulating E3 ubiquitin ligase TRIM25-mediated ubiquitination of RIG-I, a critical signaling event for the type I interferon response to WNV and other important viral pathogens.


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RGD Object Information
RGD ID: 8554587
Created: 2014-05-08
Species: All species
Last Modified: 2014-05-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.