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VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain.

Authors: Le Bras, B  Barallobre, MJ  Homman-Ludiye, J  Ny, A  Wyns, S  Tammela, T  Haiko, P  Karkkainen, MJ  Yuan, L  Muriel, MP  Chatzopoulou, E  Breant, C  Zalc, B  Carmeliet, P  Alitalo, K  Eichmann, A  Thomas, JL 
Citation: Le Bras B, etal., Nat Neurosci. 2006 Mar;9(3):340-8. Epub 2006 Feb 5.
Pubmed: (View Article at PubMed) PMID:16462734
DOI: Full-text: DOI:10.1038/nn1646

Vascular endothelial growth factor C (VEGF-C) was first identified as a regulator of the vascular system, where it is required for the development of lymphatic vessels. Here we report actions of VEGF-C in the central nervous system. We detected the expression of the VEGF-C receptor VEGFR-3 in neural progenitor cells in Xenopus laevis and mouse embryos. In Xenopus tadpole VEGF-C knockdowns and in mice lacking Vegfc, the proliferation of neural progenitors expressing VEGFR-3 was severely reduced, in the absence of intracerebral blood vessel defects. In addition, Vegfc-deficient mouse embryos showed a selective loss of oligodendrocyte precursor cells (OPCs) in the embryonic optic nerve. In vitro, VEGF-C stimulated the proliferation of OPCs expressing VEGFR-3 and nestin-positive ventricular neural cells. VEGF-C thus has a new, evolutionary conserved function as a growth factor selectively required by neural progenitor cells expressing its receptor VEGFR-3.

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RGD Object Information
RGD ID: 8554518
Created: 2014-05-08
Species: All species
Last Modified: 2014-05-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.