RGD Reference Report - Inhibition of diamine oxidase activity by metronidazole. - Rat Genome Database

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Inhibition of diamine oxidase activity by metronidazole.

Authors: Befani, O  Shiozaki, TS  Turini, P  Gerosa, P  Mondovi, B 
Citation: Befani O, etal., Biochem Biophys Res Commun. 1995 Jul 17;212(2):589-94.
RGD ID: 8554393
Pubmed: PMID:7626074   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.1995.2010   (Journal Full-text)

Metronidazole was found to be a non-competitive inhibitor of man, rabbit and rat intestinal diamine oxidases with an inhibition constant value of approximately 10(-4) M. The purified bovine serum amine oxidase was not inhibited, whereas the purified swine kidney enzyme gave similar results. These findings suggest that metronidazole and similar compounds, used as antibacterial and antiprotozoal drugs, should be given under careful control, especially when administered for long times, because a decrease of intestinal diamine oxidase activity was proven to be a risk factor for several pathologies of this organ.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Aoc1Ratputrescine oxidase activity enablesIDA PMID:7626074UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Aoc1  (amine oxidase, copper containing 1)


Additional Information