RGD Reference Report - Mover is a novel vertebrate-specific presynaptic protein with differential distribution at subsets of CNS synapses. - Rat Genome Database

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Mover is a novel vertebrate-specific presynaptic protein with differential distribution at subsets of CNS synapses.

Authors: Kremer, T  Kempf, C  Wittenmayer, N  Nawrotzki, R  Kuner, T  Kirsch, J  Dresbach, T 
Citation: Kremer T, etal., FEBS Lett. 2007 Oct 2;581(24):4727-33. Epub 2007 Sep 6.
RGD ID: 8554155
Pubmed: PMID:17869247   (View Abstract at PubMed)
DOI: DOI:10.1016/j.febslet.2007.08.070   (Journal Full-text)

Presynaptic nerve terminals contain scaffolding proteins that orchestrate neurotransmitter release at active zones. Here we describe mover, a yet unknown non-transmembrane protein that is targeted to presynaptic terminals when overexpressed in cultured neurons. Confocal immunomicroscopy revealed that mover colocalizes with presynaptic markers in the calyx of Held. In the hippocampus, mover localizes to mossy fibre terminals, but is absent from inhibitory nerve terminals. By contrast, mover localizes to inhibitory terminals throughout the cerebellar cortex. Our results suggest that mover may act in concert with generally expressed scaffolding proteins in distinct sets of presynaptic terminals.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
synaptic vesicle located_inIDA 8554155PMID:17869247UniProt 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein binding enablesIPIUniProtKB:O887378554155PMID:17869247UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Tprg1l  (tumor protein p63 regulated 1-like)


Additional Information