RGD Reference Report - Sept12 is a component of the mammalian sperm tail annulus. - Rat Genome Database

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Sept12 is a component of the mammalian sperm tail annulus.

Authors: Steels, JD  Estey, MP  Froese, CD  Reynaud, D  Pace-Asciak, C  Trimble, WS 
Citation: Steels JD, etal., Cell Motil Cytoskeleton. 2007 Oct;64(10):794-807.
RGD ID: 8553835
Pubmed: PMID:17685441   (View Abstract at PubMed)
DOI: DOI:10.1002/cm.20224   (Journal Full-text)

Since their essential role in cytokinesis was first shown in yeast, the septins have been described to function in diverse cellular contexts. The members of this unique class of GTPases are capable of binding and hydrolyzing GTP, associating with membranes and oligomerizing into higher order structures. Here we describe Sept12, a novel septin, identified in a yeast two hybrid screen using Sept5 as the bait. Sept12 contains the primary sequence elements of a septin and is capable of interacting with other septins. In addition, Sept12 purifies with bound nucleotide and binds to phosphoinositides, confirming its identity as a septin. RT-PCR and Northern blots reveal that Sept12 mRNA is expressed predominantly in testis, and this is supported by tissue Western blots. In rats, Sept12 protein levels rise upon sexual maturity and the Sept12 protein colocalizes with the annulus in isolated mature spermatozoa. Further, coexpression of Sept12 with Sept4, an essential annulus component, results in complete colocalization of both proteins into robust and highly curved filaments in CHO cells. This study suggests Sept12 may be involved in mammalian fertility.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cleavage furrow located_inIDA 8553835PMID:17685441UniProt 
septin complex part_ofIDA 8553835PMID:17685441UniProt 
stress fiber located_inIDA 8553835PMID:17685441UniProt 

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Septin12  (septin 12)
Septin5  (septin 5)


Additional Information