RGD Reference Report - Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling. - Rat Genome Database
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Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling.

Authors: Ericson, J  Rashbass, P  Schedl, A  Brenner-Morton, S  Kawakami, A  Van Heyningen, V  Jessell, TM  Briscoe, J 
Citation: Ericson J, etal., Cell. 1997 Jul 11;90(1):169-80.
RGD ID: 8553789
Pubmed: (View Article at PubMed) PMID:9230312

Distinct classes of motor neurons and ventral interneurons are generated by the graded signaling activity of Sonic hedgehog (Shh). Shh controls neuronal fate by establishing different progenitor cell populations in the ventral neural tube that are defined by the expression of Pax6 and Nkx2.2. Pax6 establishes distinct ventral progenitor cell populations and controls the identity of motor neurons and ventral interneurons, mediating graded Shh signaling in the ventral spinal cord and hindbrain.

Annotation

Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Shh  (sonic hedgehog signaling molecule)


Additional Information