RGD Reference Report - Regulation of cortical dendrite development by Slit-Robo interactions. - Rat Genome Database

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Regulation of cortical dendrite development by Slit-Robo interactions.

Authors: Whitford, KL  Marillat, V  Stein, E  Goodman, CS  Tessier-Lavigne, M  Chedotal, A  Ghosh, A 
Citation: Whitford KL, etal., Neuron. 2002 Jan 3;33(1):47-61.
RGD ID: 8553750
Pubmed: PMID:11779479   (View Abstract at PubMed)

Slit proteins have previously been shown to regulate axon guidance, branching, and neural migration. Here we report that, in addition to acting as a chemorepellant for cortical axons, Slit1 regulates dendritic development. Slit1 is expressed in the developing cortex, and exposure to Slit1 leads to increased dendritic growth and branching. Conversely, inhibition of Slit-Robo interactions by Robo-Fc fusion proteins or by a dominant-negative Robo attenuates dendritic branching. Stimulation of neurons transfected with a Met-Robo chimeric receptor with Hepatocyte growth factor leads to a robust induction of dendritic growth and branching, suggesting that Robo-mediated signaling is sufficient to induce dendritic remodeling. These experiments indicate that Slit-Robo interactions may exert a significant influence over the specification of cortical neuron morphology by regulating both axon guidance and dendritic patterning.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Robo1Ratregulation of dendrite morphogenesis involved_inIMP PMID:11779479UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Robo1  (roundabout guidance receptor 1)


Additional Information