RGD Reference Report - Notch signalling pathway mediates hair cell development in mammalian cochlea. - Rat Genome Database

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Notch signalling pathway mediates hair cell development in mammalian cochlea.

Authors: Lanford, PJ  Lan, Y  Jiang, R  Lindsell, C  Weinmaster, G  Gridley, T  Kelley, MW 
Citation: Lanford PJ, etal., Nat Genet. 1999 Mar;21(3):289-92.
RGD ID: 8553713
Pubmed: PMID:10080181   (View Abstract at PubMed)
DOI: DOI:10.1038/6804   (Journal Full-text)

The mammalian cochlea contains an invariant mosaic of sensory hair cells and non-sensory supporting cells reminiscent of invertebrate structures such as the compound eye in Drosophila melanogaster. The sensory epithelium in the mammalian cochlea (the organ of Corti) contains four rows of mechanosensory hair cells: a single row of inner hair cells and three rows of outer hair cells. Each hair cell is separated from the next by an interceding supporting cell, forming an invariant and alternating mosaic that extends the length of the cochlear duct. Previous results suggest that determination of cell fates in the cochlear mosaic occurs via inhibitory interactions between adjacent progenitor cells (lateral inhibition). Cells populating the cochlear epithelium appear to constitute a developmental equivalence group in which developing hair cells suppress differentiation in their immediate neighbours through lateral inhibition. These interactions may be mediated through the Notch signalling pathway, a molecular mechanism that is involved in the determination of a variety of cell fates. Here we show that genes encoding the receptor protein Notch1 and its ligand, Jagged 2, are expressed in alternating cell types in the developing sensory epithelium. In addition, genetic deletion of Jag2 results in a significant increase in sensory hair cells, presumably as a result of a decrease in Notch activation. These results provide direct evidence for Notch-mediated lateral inhibition in a mammalian system and support a role for Notch in the development of the cochlear mosaic.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Jag2Ratauditory receptor cell fate commitment involved_inISSUniProtKB:Q9QYE5PMID:10080181UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Jag2  (jagged canonical Notch ligand 2)


Additional Information