RGD Reference Report - Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons. - Rat Genome Database

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Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons.

Authors: Shi, S  Hayashi, Y  Esteban, JA  Malinow, R 
Citation: Shi S, etal., Cell. 2001 May 4;105(3):331-43.
RGD ID: 8553683
Pubmed: (View Article at PubMed) PMID:11348590

AMPA-type glutamate receptors (AMPA-Rs) mediate a majority of excitatory synaptic transmission in the brain. In hippocampus, most AMPA-Rs are hetero-oligomers composed of GluR1/GluR2 or GluR2/GluR3 subunits. Here we show that these AMPA-R forms display different synaptic delivery mechanisms. GluR1/GluR2 receptors are added to synapses during plasticity; this requires interactions between GluR1 and group I PDZ domain proteins. In contrast, GluR2/GluR3 receptors replace existing synaptic receptors continuously; this occurs only at synapses that already have AMPA-Rs and requires interactions by GluR2 with NSF and group II PDZ domain proteins. The combination of regulated addition and continuous replacement of synaptic receptors can stabilize long-term changes in synaptic efficacy and may serve as a general model for how surface receptor number is established and maintained.

Annotation

Gene Ontology Annotations    

Cellular Component

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Gria1  (glutamate ionotropic receptor AMPA type subunit 1)
Gria2  (glutamate ionotropic receptor AMPA type subunit 2)
Gria3  (glutamate ionotropic receptor AMPA type subunit 3)


Additional Information