RGD Reference Report - ZENON, a novel POZ Kruppel-like DNA binding protein associated with differentiation and/or survival of late postmitotic neurons.

General

ZENON, a novel POZ Kruppel-like DNA binding protein associated with differentiation and/or survival of late postmitotic neurons.
Authors:	Kiefer, H Chatail-Hermitte, F Ravassard, P Bayard, E Brunet, I Mallet, J
Citation:	Kiefer H, etal., Mol Cell Biol. 2005 Mar;25(5):1713-29.
RGD ID:	8553663
Pubmed:	PMID:15713629 (View Abstract at PubMed)
PMCID:	PMC549352 (View Article at PubMed Central)
DOI:	DOI:10.1128/MCB.25.5.1713-1729.2005 (Journal Full-text)
The rat tyrosine hydroxylase gene promoter contains an E-box/dyad motif and an octameric and heptameric element that may be recognized by classes of transcription factors highly expressed during nervous system development. In a one-hybrid genetic screen, we used these sites as targets to isolate cDNAs encoding new transcription factors present in the brain. We identified ZENON, a novel rat POZ protein that contains two clusters of Kruppel-like zinc fingers and that presents several features of a transcription factor. ZENON is found in nuclei following transient transfection with the cDNA. The N-terminal zinc finger cluster contains a DNA binding domain that interacts with the E box. Cotranfection experiments revealed that ZENON induces tyrosine hydroxylase promoter activity. Unlike other POZ proteins, the ZENON POZ domain is not required for either activation of transcription or self-association. In the embryonic neural tube, ZENON expression is restricted to neurons that have already achieved mitosis and are engaged in late stages of neuronal differentiation (late postmitotic neurons). ZENON neuronal expression persists in the adult brain; therefore, ZENON can be considered a marker of mature neurons. We propose that ZENON is involved in the maintenance of panneuronal features and/or in the survival of mature neurons.

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Biological Process

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
positive regulation of transcription by RNA polymerase II	involved_in	IDA		8553663	PMID:15713629	UniProt

Cellular Component

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
nucleus	located_in	IDA		8553663	PMID:15713629	UniProt

Molecular Function

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
DNA-binding transcription factor activity	enables	IDA		8553663	PMID:15713629	UniProt

Objects Annotated

Genes (Rattus norvegicus)

Zbtb38 (zinc finger and BTB domain containing 38)

Additional Information

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ZENON, a novel POZ Kruppel-like DNA binding protein associated with differentiation and/or survival of late postmitotic neurons.