RGD Reference Report - CPEB4 is a cell survival protein retained in the nucleus upon ischemia or endoplasmic reticulum calcium depletion. - Rat Genome Database

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CPEB4 is a cell survival protein retained in the nucleus upon ischemia or endoplasmic reticulum calcium depletion.

Authors: Kan, MC  Oruganty-Das, A  Cooper-Morgan, A  Jin, G  Swanger, SA  Bassell, GJ  Florman, H  Van Leyen, K  Richter, JD 
Citation: Kan MC, etal., Mol Cell Biol. 2010 Dec;30(24):5658-71. doi: 10.1128/MCB.00716-10. Epub 2010 Oct 11.
RGD ID: 8553637
Pubmed: PMID:20937770   (View Abstract at PubMed)
PMCID: PMC3004280   (View Article at PubMed Central)
DOI: DOI:10.1128/MCB.00716-10   (Journal Full-text)

The RNA binding protein CPEB (cytoplasmic polyadenylation element binding) regulates cytoplasmic polyadenylation and translation in germ cells and the brain. In neurons, CPEB is detected at postsynaptic sites, as well as in the cell body. The related CPEB3 protein also regulates translation in neurons, albeit probably not through polyadenylation; it, as well as CPEB4, is present in dendrites and the cell body. Here, we show that treatment of neurons with ionotropic glutamate receptor agonists causes CPEB4 to accumulate in the nucleus. All CPEB proteins are nucleus-cytoplasm shuttling proteins that are retained in the nucleus in response to calcium-mediated signaling and alpha-calcium/calmodulin-dependent kinase protein II (CaMKII) activity. CPEB2, -3, and -4 have conserved nuclear export signals that are not present in CPEB. CPEB4 is necessary for cell survival and becomes nuclear in response to focal ischemia in vivo and when cultured neurons are deprived of oxygen and glucose. Further analysis indicates that nuclear accumulation of CPEB4 is controlled by the depletion of calcium from the ER, specifically, through the inositol-1,4,5-triphosphate (IP3) receptor, indicating a communication between these organelles in redistributing proteins between subcellular compartments.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cytoplasm located_inIDA 8553637PMID:20937770UniProt 
dendrite located_inIDA 8553637PMID:20937770UniProt 
nucleus located_inIDA 8553637PMID:20937770UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Cpeb4  (cytoplasmic polyadenylation element binding protein 4)


Additional Information