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Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration.

Authors: Hardingham, GE  Patani, R  Baxter, P  Wyllie, DJ  Chandran, S 
Citation: Hardingham GE, etal., Mol Neurobiol. 2010 Aug;42(1):97-102. doi: 10.1007/s12035-010-8136-2. Epub 2010 Apr 30.
Pubmed: (View Article at PubMed) PMID:20431962
DOI: Full-text: DOI:10.1007/s12035-010-8136-2

The capacity to generate myriad differentiated cell types, including neurons, from human embryonic stem (hES) cell lines offers great potential for developing cell-based therapies and also for increasing our understanding of human developmental mechanisms. In addition, the emerging development of this technology as an experimental tool represents a potential opportunity for neuroscientists interested in mechanisms of neuroprotection and neurodegeneration. Potentially unlimited generation of well-defined functional neurons from hES and patient-specific induced pluripotent cells offers new systems to study disease mechanisms, signalling pathways and receptor pharmacology within a human cellular environment. Such systems may help in overcoming interspecies differences. Far from replacing rodent in vivo and primary culture systems, hES and induced disease-specific pluripotent stem cell-derived neurons offer a complementary resource to overcome issues of interspecies differences, accelerate drug discovery, study of disease mechanism and provide basic insight into human neuronal physiology.


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RGD Object Information
RGD ID: 8553554
Created: 2014-05-08
Species: All species
Last Modified: 2014-05-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.